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Titolo:
Neural correlates of sensory gating in the rat: Decreased Fos induction inthe lateral septum
Autore:
van Luijtelaar, G; Fabene, PF; de Bruin, N; Jongema, C; Ellenbroek, BA; Veening, JG;
Indirizzi:
Univ Nijmegen, Dept Psychol, NICI, Cognit Neurosci Sect, NL-6500 HE Nijmegen, Netherlands Univ Nijmegen Nijmegen Netherlands NL-6500 HE 0 HE Nijmegen, Netherlands Univ Verona, Dept Morphol & Biomed Sci, Sect Anat & Histol, I-37100 Verona, Italy Univ Verona Verona Italy I-37100 ct Anat & Histol, I-37100 Verona, Italy Univ Nijmegen, NICI, Dept Psychoneuropharmacol, Nijmegen, Netherlands UnivNijmegen Nijmegen Netherlands europharmacol, Nijmegen, Netherlands Univ Nijmegen, Dept Anat & Embryol, Nijmegen, Netherlands Univ Nijmegen Nijmegen Netherlands nat & Embryol, Nijmegen, Netherlands
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 2, volume: 54, anno: 2001,
pagine: 145 - 151
SICI:
0361-9230(20010115)54:2<145:NCOSGI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREPULSE INHIBITION; AUDITORY PATHWAY; SCHIZOPHRENIA; BRAIN; STIMULATION; MODEL; HIPPOCAMPUS; EXPRESSION; NEURONS; SYSTEM;
Keywords:
auditory evoked potential; inter-click interval; septo-hippocampal system; double click paradigm; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: van Luijtelaar, G Univ Nijmegen, Dept Psychol, NICI, Cognit Neurosci Sect,POB 9104, NL-6500HE Nijmegen, Netherlands Univ Nijmegen POB 9104 NijmegenNetherlands NL-6500 HE
Citazione:
G. van Luijtelaar et al., "Neural correlates of sensory gating in the rat: Decreased Fos induction inthe lateral septum", BRAIN RES B, 54(2), 2001, pp. 145-151

Abstract

In the P-50 gating or conditioning-testing paradigm in the rat, two identical click stimuli are presented with an inter-click interval of 500 ms. Thereaction towards the second click, as measured with evoked potentials, is reduced in respect to that towards the first click; this phenomenon is called sensory gating. In the present experiments, the inter-click interval wasvaried systematically and auditory evoked potentials were measured. Sensory gating was found to occur only at intervals between 500 and 1000 ms, but not at longer intervals. Fos immunohistochemistry was then performed using two groups of rats exposed to double clicks: the inter-click interval was 500 ms in the experimental group and 2500 ms in the control group. Fos induction was analyzed in selected brain structures. In the auditory pathways, Fos-immunoreactive neurons were found in both groups of rats in the inferiorcolliculus and medial geniculate body. Fos-immunoreactive cells were also examined in the septum and hippocampus. In the ventral part of the lateral septal nucleus, the labeled neurons were significantly fewer in the experimental animals compared to the control group. Smaller and non-significant quantitative differences of Fos-positive neurons were documented in the medial septum and hippocampal CA1 region. These data point out a selective decrease in the lateral septum of Fos induced by auditory sensory gating, and suggest an involvement of this structure, and possibly of other parts of the septo-hippocampal system, in sensory gating mechanisms. The results might be relevant for theories on sensory gating deficits in schizophrenia. (C) 2001 Elsevier Science Inc.

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Documento generato il 26/01/20 alle ore 10:00:07