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Titolo:
NMDA glutamate receptor stimulation is required for the expression of D2 dopamine mediated responses in apomorphine primed 6-hydroxydopamine lesionedrats
Autore:
Pollack, AE; Haisley, EC;
Indirizzi:
Brown Univ, Dept Psychol, Providence, RI 02912 USA Brown Univ Providence RI USA 02912 Dept Psychol, Providence, RI 02912 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 897, anno: 2001,
pagine: 213 - 216
SICI:
0006-8993(20010406)897:1-2<213:NGRSIR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-FOS EXPRESSION; PARKINSONS-DISEASE; BASAL GANGLIA; STRIATONIGRAL NEURONS; PROJECTION NEURONS; MESSENGER-RNA; BEHAVIOR; LOCALIZATION; GENE; D1;
Keywords:
D2 dopamine receptor; NMDA glutamate receptor; priming; c-Fos; apomorphine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Pollack, AE Univ Massachusetts, Dept Biol, 100 Morrissey Blvd, Boston, MA 02125 USA Univ Massachusetts 100 Morrissey Blvd Boston MA USA 02125 USA
Citazione:
A.E. Pollack e E.C. Haisley, "NMDA glutamate receptor stimulation is required for the expression of D2 dopamine mediated responses in apomorphine primed 6-hydroxydopamine lesionedrats", BRAIN RES, 897(1-2), 2001, pp. 213-216

Abstract

Three priming injections with the D1/D2 dopamine agonist apomorphine permits a challenge with the D2 agonist quinpirole to elicit robust contralateral rotation and ipsilateral striatal Fos expression in 6-hydroxydopamine lesioned rats. Pretreatment with NMDA glutamate antagonists MK-801 or CPP dose-dependently attenuates these quinpirole-mediated responses. These findingssuggest that concomitant NMDA receptor stimulation is required for the expression of D2-mediated responses in apomorphine primed dopamine-depleted rats. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 11:25:51