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Titolo:
The activation of mu opioid receptors promotes a small modulation of calcium currents in rat pallidal neurons
Autore:
Stefani, A; Spadoni, F; Giacomini, P; Lavaroni, F; Bernardi, G;
Indirizzi:
IRCCS Fdn, S Lucia, Italy IRCCS Fdn S Lucia ItalyIRCCS Fdn, S Lucia, Italy Univ Roma Tor Vergata, Dipartimento Neurosci, Neurol Clin, I-00133 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00133 eurol Clin, I-00133 Rome, Italy Univ La Sapienza, Clin Malattie Nervose & Mentali, Rome, Italy Univ La Sapienza Rome Italy lin Malattie Nervose & Mentali, Rome, Italy
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 897, anno: 2001,
pagine: 207 - 212
SICI:
0006-8993(20010406)897:1-2<207:TAOMOR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREPROENKEPHALIN MESSENGER-RNA; IN-SITU HYBRIDIZATION; GLOBUS-PALLIDUS; SUBTHALAMIC NUCLEUS; BASAL GANGLIA; FUNCTIONAL IMPLICATIONS; LOCALIZATION; ENKEPHALIN; EXPRESSION; INTERNEURONS;
Keywords:
opioid receptor; striato-pallidal pathway; basal ganglia; whole-cell patch-clamp;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Stefani, A IRCCS Fdn, S Lucia, Italy IRCCS Fdn S Lucia ItalyIRCCS Fdn, S Lucia, Italy
Citazione:
A. Stefani et al., "The activation of mu opioid receptors promotes a small modulation of calcium currents in rat pallidal neurons", BRAIN RES, 897(1-2), 2001, pp. 207-212

Abstract

Globus pallidus receives, from dorsal neostriatum, a dense enkephalinergicinnervation whose role is still uncertain. We examined the possibility that the activation of mu, delta or k opioid receptors modulate high-voltage-activated calcium currents in isolated GP neurons. Neither dynorphin nor DPEPE inhibited calcium current, whilst DAMGO produced a small (-16%) but consistent response, selectively antagonized by CTOP. The mu -mediated modulation required the activation of G-proteins but was voltage-independent. The pre-incubation in omega -conotoxinVIA abolished the response, implying the involvement of N-type calcium channels. These findings suggest that enkephalin may exert a direct influence on GP excitability also through post-synaptic effects. In degenerative conditions as Parkinsonism, an excessive stimulation of mu binding sites might induce a pathological inhibition of calciumsignals, thus contributing to modify the GP firing pattern and transmitterrelease. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 13:31:49