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Titolo:
The effects of intrahippocampal testosterone and flutamide on spatial localization in the Morris water maze
Autore:
Naghdi, N; Nafisy, N; Majlessi, N;
Indirizzi:
Pasteur Inst Iran, Dept Physiol & Pharmacol, Tehran 13164, Iran Pasteur Inst Iran Tehran Iran 13164 siol & Pharmacol, Tehran 13164, Iran
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 897, anno: 2001,
pagine: 44 - 51
SICI:
0006-8993(20010406)897:1-2<44:TEOITA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALE-RATS; GONADAL-STEROIDS; CALCIUM-CONCENTRATION; SEX DIFFERENCE; RADIAL-ARM; AGED RATS; MEMORY; PERFORMANCE; MODULATION; ESTRADIOL;
Keywords:
flutamide; testosterone; hippocampus; Morris water maze; spatial discrimination;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Naghdi, N Pasteur Inst Iran, Dept Physiol & Pharmacol, Pasteur Ave, Tehran13164, Iran Pasteur Inst Iran Pasteur Ave Tehran Iran 13164 ran 13164, Iran
Citazione:
N. Naghdi et al., "The effects of intrahippocampal testosterone and flutamide on spatial localization in the Morris water maze", BRAIN RES, 897(1-2), 2001, pp. 44-51

Abstract

The high density of the androgen receptors in fundamental centers of learning and memory, such as hippocampus, shows that there must be some relationships between the androgen receptors and cognitive aspects. To determine the role of hippocampal androgen receptors in spatial learning, the current research has been conducted to assess the effect of testosterone enanthate, as the agonist, and flutamide, as the antagonist, of these receptors on spatial discrimination of rats, using the Morris water maze (MWM). Adult male rats were bilaterally cannulated into the CA1 region of their hippocampus. Different groups received different doses of flutamide (2, 5, 10 and 30 mug/05 mu1) or testosterone enanthate (20, 40 and 80 mug/0.5 mu1) through the cannulas 30 min before training for 3 days. The results showed dose-dependent increases in latencies and traveled distances to find the invisible platform both in flutamide- and testosterone-treated groups as compared to the control group, with peak effects at doses of 5 mug/0.5 mu1 for flutamide and 80 mug/0.5 mu1 for testosterone. Therefore, it seems that both androgen receptor blockade and exogenous testosterone can effect spatial localizationof adult, male rats. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 06:58:10