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Titolo:
Effect of coffee consumption on bone metabolism
Autore:
Sakamoto, W; Nishihira, J; Fujie, K; Iizuka, T; Handa, H; Ozaki, M; Yukawa, S;
Indirizzi:
Hokkaido Univ, Sch Dent, Dept Biochem, Sapporo, Hokkaido 060, Japan Hokkaido Univ Sapporo Hokkaido Japan 060 em, Sapporo, Hokkaido 060, Japan Hokkaido Univ, Sch Dent, Dept Oral Pathol, Sapporo, Hokkaido 060, Japan Hokkaido Univ Sapporo Hokkaido Japan 060 ol, Sapporo, Hokkaido 060, Japan Hokkaido Univ, Sch Med, Cent Res Inst, Sapporo, Hokkaido 060, Japan Hokkaido Univ Sapporo Hokkaido Japan 060 st, Sapporo, Hokkaido 060, Japan
Titolo Testata:
BONE
fascicolo: 3, volume: 28, anno: 2001,
pagine: 332 - 336
SICI:
8756-3282(200103)28:3<332:EOCCOB>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESISTANT ACID-PHOSPHATASE; HIP FRACTURE; RISK-FACTORS; CAFFEINE; WOMEN; OSTEOPOROSIS; ADOLESCENTS; PHOSPHORUS; CELLS;
Keywords:
coffee; bone metabolism; calcium; deoxypyridinoline; osteocalcin; cytokines; osteoclast;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Sakamoto, W Hokkaido Univ, Sch Dent, Dept Biochem, Sapporo, Hokkaido 060, Japan Hokkaido Univ Sapporo Hokkaido Japan 060 Hokkaido 060, Japan
Citazione:
W. Sakamoto et al., "Effect of coffee consumption on bone metabolism", BONE, 28(3), 2001, pp. 332-336

Abstract

The effects of coffee on bone metabolism are still controversial, althoughseveral studies have suggested that caffeine and/or heavy coffee consumption is associated with a significant increase in risk of fracture, osteoporosis, and periodontal disease. Therefore, we sought to clarify the relationship between coffee consumption and bone metabolism using male Wistar rats. Forty-eight male Wistar rats were assigned to three treatment groups including a control-diet group (control, n = 16, coffee-free diet), a 0.62% coffee-diet group (low caffeine, n = 16, diet supplemented with 6.2 g/kg of the control diet), and a 1.36% coffee-diet group (high caffeine, n = 16, diet supplemented with 13.6 g/kg of the control diet), and animals were maintained on an experimental diet for 140 days. Although caffeine in serum was not detected in rats fed the control diet, low-intake coffee for 140 days led to an increase in caffeine concentration to 0.53 +/- 0.11 mug/mL and high-intake coffee led to an increase of 1.77 +/- 0.22 mug/mL. No significant differences in body weight change, serum and urinary biochemical markers of bone metabolism, and bone histomorphometry were found between the coffee-diet groups and the control-diet groups, except that urinary phosphorus excretion after 140 days of both coffee diets was significantly increased compared with controls (p < 0.05). In addition, the coffee diets were not associatedwith differences in tumor necrosis factor-<alpha> and interleukin-6, whichhave been implicated in the pathogenesis of bone loss together with interleukin-1 beta. In conclusion, the present study strongly indicates that coffee does not stimulate bone loss in rats. (Bone 28:332-336; 2001) (C) 2001 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:27:53