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Titolo:
A nonhuman primate model of age-related bone loss: A longitudinal study inmale and premenopausal female rhesus monkeys
Autore:
Black, A; Tilmont, EM; Handy, AM; Scott, WW; Shapses, SA; Ingram, DK; Roth, GS; Lane, MA;
Indirizzi:
NIA, Gerontol Res Ctr, Neurosci Lab, Baltimore, MD 21224 USA NIA Baltimore MD USA 21224 Res Ctr, Neurosci Lab, Baltimore, MD 21224 USA Johns Hopkins Univ Hosp, Dept Radiol, Baltimore, MD USA Johns Hopkins UnivHosp Baltimore MD USA Dept Radiol, Baltimore, MD USA Rutgers State Univ, Dept Nutr Sci, New Brunswick, NJ 08903 USA Rutgers State Univ New Brunswick NJ USA 08903 New Brunswick, NJ 08903 USA
Titolo Testata:
BONE
fascicolo: 3, volume: 28, anno: 2001,
pagine: 295 - 302
SICI:
8756-3282(200103)28:3<295:ANPMOA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-COMPOSITION; MINERAL DENSITY; SERUM OSTEOCALCIN; NORMAL MEN; WOMEN; MASS; OSTEOPOROSIS; MENOPAUSE; TURNOVER; RISK;
Keywords:
bone loss; age; nonhuman primates; rhesus; dual-energy X-ray absorptiometry (DXA); bone turnover;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Black, A NIA, Gerontol Res Ctr, Neurosci Lab, 5600 Nathan Shock Dr, Baltimore, MD 21224 USA NIA 5600 Nathan Shock Dr Baltimore MD USA 21224 ore, MD 21224 USA
Citazione:
A. Black et al., "A nonhuman primate model of age-related bone loss: A longitudinal study inmale and premenopausal female rhesus monkeys", BONE, 28(3), 2001, pp. 295-302

Abstract

Aging is associated with gradual bone loss in men and premenopausal women,with an accelerated rate of loss after menopause in women. Although many studies have investigated bone loss due to surgically induced estrogen depletion, little is known regarding normal age-related changes in bone mass in animal models, We used dual-energy X-ray absorptiometry (DXA) to measure bone mineral density (BMD), bone mineral content (BMC), and projected area (PA) at four skeletal sites over 4 years in 20 premenopausal female (8-23 years) and 29 male (8-27 years) rhesus monkeys (Macaca mulatta). Forearm BMD declined with age in both male and female monkeys, Lean mass was positively associated with BMD at all sites in males acid with the distal radius in females, Serum osteocalcin declined and urinary cross-links increased with age in males but not females. Serum 25-hydroxyvitamin D concentrations decreased with ape in females, and a similar trend was observed in males. In conclusion, an age-related decline in forearm BMD was observed in male and female rhesus monkeys, Total body BMC declined over time in older females, witha similar trend in males. Changes in markers of bone turnover with age were also observed in male monkeys. The results of this longitudinal study suggest that the rhesus monkey is a potential model for age-related changes inthe human skeleton. (Bone 28:395-302; 2001) (C) 2001 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:47:31