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Titolo:
Maintenance of cortical bone in human parathyroid hormone(1-84)-treated ovariectomized rats
Autore:
Samnegard, E; Iwaniec, UT; Cullen, DM; Kimmel, DB; Recker, RR;
Indirizzi:
Creighton Univ, Osteoporosis ReS Ctr, Omaha, NE 68178 USA Creighton Univ Omaha NE USA 68178 teoporosis ReS Ctr, Omaha, NE 68178 USA
Titolo Testata:
BONE
fascicolo: 3, volume: 28, anno: 2001,
pagine: 251 - 260
SICI:
8756-3282(200103)28:3<251:MOCBIH>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESTROGEN REPLACEMENT THERAPY; ANTIRESORPTIVE AGENTS; POSTMENOPAUSAL WOMEN; CANCELLOUS BONE; HORMONE 1-38; FEMORAL-NECK; AGED RATS; MASS; STRENGTH; OSTEOPOROSIS;
Keywords:
17 beta-estradiol; risedronate; adult rats; densitometry; histomorphometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Samnegard, E Huddinge Univ Hosp, Karolinska Inst, Dept Orthopaed Surg, S-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden S-14186 Huddinge, Sweden
Citazione:
E. Samnegard et al., "Maintenance of cortical bone in human parathyroid hormone(1-84)-treated ovariectomized rats", BONE, 28(3), 2001, pp. 251-260

Abstract

The purpose of this cross-sectional study,vas to evaluate the effects of human parathyroid hormone(1-84) (hPTH) followed by maintenance treatment with 17 beta -estradiol (E-2), risedronate (Ris), or a reduced dose of hPTH (LowPTH) on cortical hone in the ovariectomized (ovx) rat. Eight groups of ovx and one group of intact female rats (3.5 months) were left untreated for 11 weeks. For the following 12 weeks, four groups received subcutaneous injections of hPTH (75 mug/kg per day on 3 days/week) and four groups receivedvehicle, Treatments,were then changed to E-2 (10 mug/kg per day on 2 days/week), Ris (3 mug/kg per day on 3 days/week), LowPTH (25 mug/kg per day on 3 days/week), or,vehicle. Bone tissue was collected at weeks -11 (baseline), 0 (ovx effect), 12 (hPTH effect), 24, 36, and 48 (maintenance effect). Bone mineral density (BMD) and bone mineral content (BMC) of the diaphyseal femur and total cross-sectional area (Tt.Ar), marrow: area (Ma.Ar), corticalarea (Ct.Ar), and periosteal and endocortical bone formation of the tibia were measured. Ovariectomy resulted in loner BMD (,weeks 0-48), unaffected BMC, and greater Tt.Ar (weeks 12 and 36), Ma.Ar (week 48), and Ct.Ar (weeks0 and 12) compared with intact rats, Endocortical and periosteal bone formation were greater in the ovx than in the intact rats up to 23 weeks postovariectomy. Treatment of ovx rats with hPTH for 12 weeks resulted in greatercortical BMD, BMC, and endocortical hone formation than in intact or ovx controls. In ovx rats pretreated with hPTH and then treated with Ris for 36 weeks, BMD and BMC were greater and Ma.Ar was smaller than in ovx controls,In ovx rats pretreated with hPTH and then treated with LowPTH, BMD, BMC, Ct.Ar, and endocortical bone formation were greater and Ma.Ar was smaller than in ovx controls. Treatment of hPTH-pretreated rats with E-2 for 36 weeksdid not affect cortical BMD, BMC, and Ct.Ar, although periosteal bone formation was lower in the E-2 group compared with the ovx group. Thus, in ovariectomized rats, cortical bone gained by 12 weeks of hPTH treatment was maintained for up to 36 weeks by treatment with risedronate or low-dose hPTH, but not with 17 beta -estradiol. (Bone 28:251-260; 2001) (C) 2001 by Elsevier Science Inc, All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 11:28:56