Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Bone tissue and its mineralization in aged estrogen-depleted rats after long-term intermittent treatment with parathyroid hormone (PTH) analog SDZ PTS 893 or human PTH(1-34)
Autore:
Kneissel, M; Boyde, A; Gasser, JA;
Indirizzi:
Novartis Pharma AG, Bone Metab Unit, Therapeut Area Arthritis & Bone Metab, CH-4002 Basel, Switzerland Novartis Pharma AG Basel Switzerland CH-4002 CH-4002 Basel, Switzerland Univ Coll London, Dept Anat & Dev Biol, Hard Tissue Res Unit, London, England Univ Coll London London England , Hard Tissue Res Unit, London, England
Titolo Testata:
BONE
fascicolo: 3, volume: 28, anno: 2001,
pagine: 237 - 250
SICI:
8756-3282(200103)28:3<237:BTAIMI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCANNING ELECTRON-MICROSCOPY; OVARIECTOMIZED RATS; CANCELLOUS BONE; TRABECULAR BONE; CORTICAL BONE; SODIUM-FLUORIDE; POSTMENOPAUSAL WOMEN; VERTEBRAL BODY; SKELETAL SITES; ILIAC CREST;
Keywords:
parathyroid hormone (PTH); long-term treatment; aged estrogen-depleted rats; bone turnover; bone structure; bone mineralization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Kneissel, M Novartis Pharma AG, Bone Metab Unit, Therapeut Area Arthritis & Bone Metab, K-125 10 15, CH-4002 Basel, Switzerland Novartis Pharma AG K-125 10 15 Basel Switzerland CH-4002 land
Citazione:
M. Kneissel et al., "Bone tissue and its mineralization in aged estrogen-depleted rats after long-term intermittent treatment with parathyroid hormone (PTH) analog SDZ PTS 893 or human PTH(1-34)", BONE, 28(3), 2001, pp. 237-250

Abstract

Intermittently administered parathyroid hormone (PTH) is a potent bone anabolic agent, We aimed to determine the impact of long-term treatment with PTH on bone structure, dynamics, and mineralization. We ovariectomized (ovx)1-year-old rats with the exception of a baseline and a sham-operated group. Twelve weeks later, a 36 week treatment with PTH analog SDZ PTS 893 (12.5, 25, 50, 100 mug/kg), human PTH(1-34) (25, 50, 100 mug/kg), or vehicle (ovx, sham) was initiated. Bone dynamics, structure, and mineralization were evaluated in the lumbar spine and in the femoral diaphysis, Cancellous bone turnover was elevated 12 weeks postovariectomy in estrogen-deficient, vehicle-treated animals, but returned to the level of the sham group by 48 weeks, The animals experienced substantial cancellous bone loss associated with a reduction of trabecular number and presented with a partly rod-like trabecular network. After 36 weeks of treatment with SDZ PTS 893 or human PTH(1-34), cancellous bone formation rates and turnover were raised in all treated groups compared with age-matched controls, The mineral apposition rate was increasing with dose, This amplified matrix synthesis led to trabecular thickening, but not to an increase in trabecular number, resulting in a crude, plate-like cancellous network with a high hone volume fraction. Fluorochrome label-based cortical bone dynamics demonstrated that a thick ring of new bone was formed at the endocortex by activation of modeling drifts during treatment, Treatment-induced cortical bone formation was increased with dose at the subperiosteal and endocortical envelopes, but substantially higher at the latter, Intracortical bone turnover was elevated near the endocortex, Bone mineralization was undisturbed in all compartments. The average degree of mineralization was lowered slightly, reflecting the increased portion of new bone Formed during treatment. In summary, the main anabolic effect was mediated for both peptides by an increase in bone apposition with dose, persisting throughout treatment that lasted more than one third of the lifespan of the rats, and direct activation of bone-forming surfaces. As a result, a substantial amount of new bone, maintained at elevated turnover and adequate mineralization levels, formed predominantly at compartments exposed to bone marrow. (Bone 28:237-250; 2001) (C) 2001 by Elsevier Science Inc, All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:18:34