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Titolo:
Polymorphism insertion/deletion of the ACE gene and ambulatory blood pressure circadian variability in essential hypertension
Autore:
Julve, R; Chaves, FJ; Rovira, E; Pascual, JM; Miralles, A; Armengod, ME; Redon, J;
Indirizzi:
Univ Valencia, Hosp Clin, Hyptens Clin, Valencia 46010, Spain Univ Valencia Valencia Spain 46010 , Hyptens Clin, Valencia 46010, Spain Univ Valencia, Hosp Sagunto, Valencia 46010, Spain Univ Valencia Valencia Spain 46010 , Hosp Sagunto, Valencia 46010, Spain Univ Valencia, Fdn Valenciana Invest Biomed, Inst Invest Citol, Valencia 46010, Spain Univ Valencia Valencia Spain 46010 t Invest Citol, Valencia 46010, Spain
Titolo Testata:
BLOOD PRESSURE MONITORING
fascicolo: 1, volume: 6, anno: 2001,
pagine: 27 - 32
SICI:
1359-5237(200102)6:1<27:PIOTAG>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING ENZYME; JAPANESE HYPERTENSIVES; DELETION POLYMORPHISM; NON-DIPPERS; MICROALBUMINURIA;
Keywords:
ambulatory blood pressure; circadian variability; I/D polymorphism of the ACE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Redon, J Univ Valencia, Hosp Clin, Hyptens Clin, Avda Blasco Ibanez 17, Valencia 46010, Spain Univ Valencia Avda Blasco Ibanez 17 Valencia Spain 46010 , Spain
Citazione:
R. Julve et al., "Polymorphism insertion/deletion of the ACE gene and ambulatory blood pressure circadian variability in essential hypertension", BL PRESS M, 6(1), 2001, pp. 27-32

Abstract

Objective The objective of the present study was to analyze the influence of the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme on ambulatory blood pressure values and circadian variability in untreated patients with hypertension. Material and methods Ninety-nine essential hypertensive patients, less than 50 years old (mean age 39.5 +/- 7.0 years), previously untreated with antihypertensive drugs were included, Twenty-four hour ambulatory blood pressure monitoring (ABPM) was performed with a Spacelabs (90202 and 90207) monitor, during a regular working day in unrestricted ambulatory conditions. TheI/D polymorphism of the ACE was determined by PCR. Results The distributions of genotypes were in Hardy-Weinberg equilibrium:I=17 (17%), ID=41 (41.5%), DD=41 (41.5%). No significant differences were present among the groups in terms of age, sex, and biochemical and lipid profiles, The average of 24-h ambulatory blood pressure was slightly higher in patients with the DD genotype as compared with patients with the II and ID genotypes. This was the result of higher nighttime blood pressure values,because no differences in blood pressure were observed during daytime. Thesystolic blood pressure (SBP) day:night ratio, as an estimate of circadianvariability, was significantly lower in subjects homozygous for the D allele than it was in patients carrying the I allele (1.13 +/- 0.09 vs. 1.17 +/- 0.08, P= 0.014), The subjects in the lowest tertile of the SEP day:night ratio, exhibited a higher frequency of the D allele when compared with those in the middle tertile (0.74 vs. 0.59, P < 0.05) or with those in the highest tertile (0.74 vs. 0.54, P < 0.01). By using two-way ANOVA with repeatedmeasures, significant differences in SEP variation over time were observedwhen comparing homozygous for the D allele with subjects carrying the \ allele (F = 2.11, P = 0.002). Conclusions Among the genotypes of the I/D polymorphism, subjects carryingDD genotype showed a blunted decline of the physiological nocturnal fall of blood pressure that was significant for SEP. (C) 2001 Lippincott Williams& Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:27:41