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Titolo:
Advanced glycation end-products are responsible for the impairment of corpus cavernosal smooth muscle relaxation seen in diabetes
Autore:
Cartledge, JJ; Eardley, I; Morrison, JFB;
Indirizzi:
St Jamess Univ Hosp, Pyrah Dept Urol, Leeds LS9 7TF, W Yorkshire, England St Jamess Univ Hosp Leeds W Yorkshire England LS9 7TF Yorkshire, England United Arab Emirates Univ, Fac Med & Hlth Sci, Dept Physiol, Al Ain, U Arab Emirates United Arab Emirates Univ Al Ain U Arab Emirates l Ain, U Arab Emirates
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 4, volume: 87, anno: 2001,
pagine: 402 - 407
SICI:
1464-4096(200103)87:4<402:AGEARF>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCOSYLATED HUMAN HEMOGLOBIN; NITRIC-OXIDE; AMINOGUANIDINE TREATMENT; ENDOTHELIUM; COMPLICATIONS; DYSFUNCTION; MECHANISMS; LIPIDS; RATS; AGE;
Keywords:
erectile dysfunction; diabetes mellitus; advanced glycation end-products (AGEs); aminoguanidine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Cartledge, JJ St Jamess Univ Hosp, Pyrah Dept Urol, Beckett St, Leeds LS9 7TF, W Yorkshire, England St Jamess Univ Hosp Beckett St Leeds W Yorkshire England LS9 7TF
Citazione:
J.J. Cartledge et al., "Advanced glycation end-products are responsible for the impairment of corpus cavernosal smooth muscle relaxation seen in diabetes", BJU INT, 87(4), 2001, pp. 402-407

Abstract

Objective To determine if advanced glycation products (AGEs) are responsible for the lower neuronal and endothelial-derived nitric oxide (NO)mediatedrelaxation of corpus cavernosum in tissue in diabetic rats than in controlrats. Materials and methods Diabetes was induced in male Wistar rats by an intraperitoneal injection with streptozotocin (60 mg/kg). One group of diabetic rats was given free access to water and standard diet. A second group was given standard diet and aminoguanidine with their water (50 mg/100 mL) from the initiation of diabetes. Two groups of rats that were not diabetic actedas age-matched controls. After 8 weeks animals were killed by cervical dislocation, corpus cavernosal tissue strips harvested and in an organ bath tomeasure isometric After 90 min of equilibration at optimal resting tensionand contraction with 1 mu mol/L noradrenaline, the response to either acetylcholine or electrical field stimulation (EFS) after adding guanethidine (5 mu mol/L) and atropine (1 mu mol/L) was determined for each group. Results There was no difference between the baseline characteristics of all the experimental groups. After 8 weeks the mean body mass and glycosylated haemoglobin (HbA(1c)) were significantly greater in the diabetic than in control animals. Aminoguanidine had no effect on the recorded body mass or HbA(1c). The in vitro relaxation response to the application of acetylcholine or EFS of tissue strips from age-matched control animals fed a standard diet and those supplemented with aminoguanidine were the same. The administration of aminoguanidine to diabetic animals for 8 weeks reversed the expected impaired relaxation response to acetylcholine; the response to EFS was similar. Conclusion AGEs are more prevalent in erectile tissue from diabetic than in control animals. Aminoguanidine reversed the impairment in neuronal and endothelial NO-mediated penile smooth muscle relaxation seen in diabetes. Asaminoguanidine prevents AGE formation, erectile dysfunction in diabetes isprobably caused partly by the generation of AGEs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:30:26