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Titolo:
Nitric oxide-mediated corpus cavernosal smooth muscle relaxation is impaired in ageing and diabetes
Autore:
Cartledge, JJ; Eardley, I; Morrison, JFB;
Indirizzi:
St Jamess Univ Hosp, Pyrah Dept Urol, Leeds LS9 7TF, W Yorkshire, England St Jamess Univ Hosp Leeds W Yorkshire England LS9 7TF Yorkshire, England United Arab Emirates Univ, Fac Med & Hlth Sci, Dept Physiol, Al Ain, U Arab Emirates United Arab Emirates Univ Al Ain U Arab Emirates l Ain, U Arab Emirates
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 4, volume: 87, anno: 2001,
pagine: 394 - 401
SICI:
1464-4096(200103)87:4<394:NOCCSM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERECTILE DYSFUNCTION; BINDING-SITES; IMPOTENCE; SYNTHASE; RABBIT; RAT; LOCALIZATION; PREVALENCE; MELLITUS; TISSUE;
Keywords:
diabetes; nitric oxide; advanced glycation end products; impotence; corpus cavernosal smooth muscle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Cartledge, JJ St Jamess Univ Hosp, Pyrah Dept Urol, Beckett St, Leeds LS9 7TF, W Yorkshire, England St Jamess Univ Hosp Beckett St Leeds W Yorkshire England LS9 7TF
Citazione:
J.J. Cartledge et al., "Nitric oxide-mediated corpus cavernosal smooth muscle relaxation is impaired in ageing and diabetes", BJU INT, 87(4), 2001, pp. 394-401

Abstract

Objective To examine nitric-oxide (NO)-mediated relaxation in cavernosal smooth muscle in a rat model of diabetes, as previous experiments showed that HbA(1c) (an isoform of glycosylated haemoglobin and a marker of long-termdiabetic control) impaired NO-mediated relaxation of normal corpus cavernosal tissue through the generation of superoxide anions. Materials and methods Eight weeks after the induction of diabetes, male Wistar rats were killed and cavernosal tissue obtained. Strips were contracted with 1 mu mol/L noradrenaline before applying acetylcholine or electricalfield stimulation (EFS) or sodium nitroprusside (SNP). Relaxation responses were repeated in the presence of L-arginine (100 mu mol/L), indomethacin (10 mu mol/L) or superoxide dismutase (SOD, 120 IU/ mt). Young and age-matched control animals were examined in the same way. Results Eight weeks of uncontrolled diabetes caused a significant impairment in mean relaxation responses to acetylcholine (P<0.05) and to EFS (P<0.05), but not to SNP, compared with young and age-matched controls, respectively. L-arginine, indomethacin and SOD had no significant effect on this impairment. Ageing caused a lesser but significant impairment in EFS-mediated cavernosal smooth muscle relaxation (P<0.05). Conclusion Diabetes impairs endothelial and neuronal NO-mediated cavernosal smooth muscle relaxation in rats in vitro. This effect is not mediated byan alteration in the intracellular action of NO, the availability of NO, superoxide anion inactivation of NO or the generation of constrictor prostanoids. It is possible that cholesterol or advanced glycation end products are responsible for the effect of diabetes on penile smooth function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 08:08:24