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Titolo:
Tumour angiogenesis and Ki-67 expression in phaeochromocytoma
Autore:
Ohji, H; Sasagawa, I; Iciyanagi, O; Suzuki, Y; Nakada, T;
Indirizzi:
Yamagata Univ, Sch Med, Dept Urol, Yamagata 9909585, Japan Yamagata Univ Yamagata Japan 9909585 Dept Urol, Yamagata 9909585, Japan
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 4, volume: 87, anno: 2001,
pagine: 381 - 385
SICI:
1464-4096(200103)87:4<381:TAAKEI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODY KI-67; CELL-PROLIFERATION; PARAFFIN SECTIONS; FLOW-CYTOMETRY; PHEOCHROMOCYTOMAS; ANTIGEN; MIB-1; MARKER;
Keywords:
phaeochromocytoma; angiogenesis; CD34; MIB-1; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Sasagawa, I Yamagata Univ, Sch Med, Dept Urol, 2-2-2 Iidanishi, Yamagata 9909585, Japan Yamagata Univ 2-2-2 Iidanishi Yamagata Japan 9909585 5, Japan
Citazione:
H. Ohji et al., "Tumour angiogenesis and Ki-67 expression in phaeochromocytoma", BJU INT, 87(4), 2001, pp. 381-385

Abstract

Objective To determine the expression of CD34 (to evaluate vascularity) and Ki-67 (as a proliferative index) in a variety of phaeochromocytomas and thus assess the utility of these markers as possible predictors of malignancy. Patients and methods Deparaffinized tissue sections from 21 patients with benign and four with malignant phaeochromocytoma were assessed immunohistochemically to evaluate microvascular counts (using CD34 antigen) and the proliferative index (Ki-67 antigen, monoclonal antibody MIB-1). Results There was no statistical association between high microvascular counts and malignancy, but there was between the MIB-1 score and malignancy (P < 0.001). Conclusions A high MIB-1 score in phaeochromocytoma suggests malignant behaviour in the component cells. The MIB-1 score may be a useful indicator for diagnosing malignant phaeochromocytoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:15:38