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Titolo:
The serum level of the amino-terminal propeptide of type I procollagen is a sensitive marker for prostate cancer metastasis to bone
Autore:
Koizumi, M; Yonese, J; Fukui, I; Ogata, E;
Indirizzi:
Canc Inst Hosp, Dept Nucl Med, Toshima Ku, Tokyo 1708455, Japan Canc Inst Hosp Tokyo Japan 1708455 Med, Toshima Ku, Tokyo 1708455, Japan Canc Inst Hosp, Dept Urol, Tokyo 1708455, Japan Canc Inst Hosp Tokyo Japan 1708455 Hosp, Dept Urol, Tokyo 1708455, Japan Canc Inst Hosp, Dept Internal Med, Tokyo 1708455, Japan Canc Inst Hosp Tokyo Japan 1708455 pt Internal Med, Tokyo 1708455, Japan
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 4, volume: 87, anno: 2001,
pagine: 348 - 351
SICI:
1464-4096(200103)87:4<348:TSLOTA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOLIC MARKERS; COLLAGEN; EXPRESSION; SCAN;
Keywords:
PINP; prostate cancer; bone metastasis; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Koizumi, M Canc Inst Hosp, Dept Nucl Med, Toshima Ku, 1-37-1 Kami Ikebukuro, Tokyo 1708455, Japan Canc Inst Hosp 1-37-1 Kami Ikebukuro Tokyo Japan 1708455 Japan
Citazione:
M. Koizumi et al., "The serum level of the amino-terminal propeptide of type I procollagen is a sensitive marker for prostate cancer metastasis to bone", BJU INT, 87(4), 2001, pp. 348-351

Abstract

Objective To assess the level of a bone-formation marker, the amino-terminal propeptide of type I procollagen (PINP), for its utility in indicating bone metastasis in patients with prostate cancer. Patients and methods Several bone formation markers, i.e. PINP, the carboxy-terminal propeptide of type I procollagen (PICP), bone-specific alkaline phosphatase (BALP), and bone Gla protein (BGP), a bone resorption marker (pyridinoline cross-linked carboxy-terminal telopeptide, ICTP), and prostate specific antigen (PSA) were measured in 40 patients without and 25 patientswith bone metastasis. No patient had undergone previous treatment, except for six who developed bone metastasis while undergoing hormone therapy. Results All markers except BGP were significantly higher in patients with bone metastasis than in those without. The levels of PINP correlated best with the extent of disease, although the levels of PSA, BALP and ICTP also correlated well. While PINP had the largest area under the receiver-operatorcharacteristic curve, PSA, BALP and ICTP also produced useful curves. Conclusion The bone formation marker PINP seems to be useful for discriminating patients with and without bone metastasis. PINP may help in the earlyand accurate diagnosis of bone metastasis in such patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:26:45