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Titolo:
Prognostic evaluation of transcatheter arterial embolization for unresectable renal cell carcinoma with distant metastasis
Autore:
Onishi, T; Oishi, Y; Suzuki, Y; Asano, K;
Indirizzi:
Jikei Univ, Sch Med, Dept Urol, Tokyo 1258506, Japan Jikei Univ Tokyo Japan 1258506 Sch Med, Dept Urol, Tokyo 1258506, Japan
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 4, volume: 87, anno: 2001,
pagine: 312 - 315
SICI:
1464-4096(200103)87:4<312:PEOTAE>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ONCOLOGY-GROUP; NEPHRECTOMY; ETHANOL;
Keywords:
renal cell carcinoma; metastasis; embolization; ethanol; survival;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Onishi, T Jikei Univ, Sch Med, Aoto Univ Hosp, Dept Urol,Katsushika Ku, 41-2,6 Chome, Tokyo 1258506, Japan Jikei Univ 41-2,6 Chome Tokyo Japan 1258506 okyo 1258506, Japan
Citazione:
T. Onishi et al., "Prognostic evaluation of transcatheter arterial embolization for unresectable renal cell carcinoma with distant metastasis", BJU INT, 87(4), 2001, pp. 312-315

Abstract

Objective To evaluate the efficacy of transcatheter arterial embolization (TAE) in patients with unresectable renal cell carcinoma (RCC) and distant metastasis at the time of diagnosis. Patients and methods The study included 54 patients with histologically defined RCC (by biopsy in 28 and autopsy in 26) who were unable to undergo nephrectomy mainly because their performance status was poor (score greater than or equal to2). The patients were classified into two groups; 24 patients who underwent TAE with ethanol and 30 patients who did not. The two groups were compared for several clinical factors, mainly focusing on the prognosis. Results There were no significant differences in the clinical factors, including performance status, tumour diameter, vascular invasion, lymph node involvement, adjuvant therapy, metastatic organs or the number of metastasesbetween the groups. However, the proportion of patients with para-neoplastic signs in those undergoing TAE was greater than that in those not, and the difference was significant (chi squared 0.35, P<0.05). The median survival of the two groups was 229 days (TAE) and 116 days (no TAE). The 1-, 2- and 3-year survival rates in the TAE group were 29%, 15% and 10%, respectively, and in those not undergoing TAE were 13%, 7% and 3%, respectively. Thoseundergoing TAE had a significantly better prognosis than those who did not(P=0.019). The adverse effects in patients undergoing TAE with ethanol included fever, back pain on the affected side, nausea and vomiting, but all the patients recovered from these adverse effects. Conclusion TAE with ethanol is a safe and effective treatment for patientswith unresectable disseminated RCC and a poor performance status; TAE withethanol not only induces ablation of the primary tumour, but also prolongssurvival.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/05/20 alle ore 15:45:16