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Titolo:
Predicted profiles of ion concentrations in olfactory cilia in the steady state
Autore:
Lindemann, B;
Indirizzi:
Univ Saarlandes, Dept Physiol, D-66421 Homburg, Germany Univ Saarlandes Homburg Germany D-66421 hysiol, D-66421 Homburg, Germany
Titolo Testata:
BIOPHYSICAL JOURNAL
fascicolo: 4, volume: 80, anno: 2001,
pagine: 1712 - 1721
SICI:
0006-3495(200104)80:4<1712:PPOICI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOTIDE-GATED CHANNELS; RECEPTOR-CELLS; ULTRASTRUCTURAL-LOCALIZATION; CHLORIDE CURRENT; TRANSDUCTION; NEURONS; EPITHELIUM; MODEL; AMPLIFICATION; CONDUCTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Lindemann, B Univ Saarlandes, Dept Physiol, D-66421 Homburg, Germany Univ Saarlandes Homburg Germany D-66421 21 Homburg, Germany
Citazione:
B. Lindemann, "Predicted profiles of ion concentrations in olfactory cilia in the steady state", BIOPHYS J, 80(4), 2001, pp. 1712-1721

Abstract

The role of ciliary geometry for transduction events was explored by numerical simulation. The changes in intraciliary ion concentrations, suspected to occur during transduction, could thus be estimated. The case of a singleexcised cilium, having a uniform distribution of membrane channels, voltage clamped to -80 mV, was especially investigated, The axial profile of membrane voltage was that of a leaky cable, The Ca2+ concentration profile tended to show a maximum in proximal segments, due to a preponderance of Ca2+ inflow over Ca2+ export at those locations. The local increase in Ca2+ concentration activated Cl- channels. The resulting current caused a local drop in Cl- concentration, especially at the tip of the cilium and in distal segments, accompanied by a drop in ciliary K+ concentration. In consequence, the membrane Cl- current was low in distal segments but stronger in proximalsegments, where resupply was sufficient. The model predicts that the Cl- depletion will codetermine the time course of the receptor potential or current and the ciliary stimulus-response curve. In conclusion, when modeling with transduction elements presently known to participate, the ciliary geometry has large effects on ion distributions and transduction currents because ciliary ion transport is limited by axial electrodiffusion.

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Documento generato il 02/04/20 alle ore 13:01:19