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Titolo:
Renal handling of zinc in insulin-dependent diabetes mellitus patients
Autore:
Brandao-Neto, J; Silva, CAB; Shuhama, T; Silva, JA; Oba, L;
Indirizzi:
Univ Fed Rio Grande Norte, Ctr Ciencias Saude, Unidade Endocrinol & Metab,BR-59010180 Natal, RN, Brazil Univ Fed Rio Grande Norte Natal RN Brazil BR-59010180 BCNatal, RN, Brazil
Titolo Testata:
BIOMETALS
fascicolo: 1, volume: 14, anno: 2001,
pagine: 75 - 80
SICI:
0966-0844(200103)14:1<75:RHOZII>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOLERANCE-TEST; METABOLISM; EXCRETION; KINETICS; HEALTHY; SERUM;
Keywords:
IDDM patients; C-peptide; insulin; glucagon; cortisol; urinary zinc excretion; renal zinc clearance; venous zinc tolerance test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Brandao-Neto, J Univ Fed Rio Grande Norte, Ctr Ciencias Saude, Unidade Endocrinol & Metab,CP 244, BR-59010180 Natal, RN, Brazil Univ Fed Rio Grande Norte CP 244 Natal RN Brazil BR-59010180 BC
Citazione:
J. Brandao-Neto et al., "Renal handling of zinc in insulin-dependent diabetes mellitus patients", BIOMETALS, 14(1), 2001, pp. 75-80

Abstract

Hyperzincuria is a common feature in diabetic patients, which is still notunderstood. Based on the above consideration, the aim of the present studywas to investigate the renal handling of zinc in insulin-dependent diabetes mellitus (IDDM) patients. The glomerular filtration rate, urinary zinc excretion, zinc clearance, zinc clearance/creatinine clearance ratio, zinc tubular reabsorption, glycosuria, plasma glucose, C-peptide, glucagon, and cortisol were investigated in 10 normal individuals (Group C1 and Group C2, respectively) and 10 IDDM patients (Group E1: hyperglycemic and glycosuric and Group E2: normoglycemic and aglycosuric) during placebo or venous zinc tolerance test. The results showed that urinary zinc excretion and renal zinc clearance were increased after zinc injection in normal individuals (Group C2) and IDDM patients (Groups E1 and E2) when compared with normal individuals-placebo (Group C1). However, these renal parameters were statistically more significant in the hyperglycemic and glycosuric diabetics (Group E1). Because patients in Group E1 had the lowest plasma C-peptide levels and showed a strong negative correlation between CZn++/Ccr ratio and this hormone, we suggest that in this setting insulin inhibits urinary zinc excretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 23:04:48