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Titolo:
Effects of a 2-to 4-week course of repetitive transcranial magnetic stimulation (rTMS) on neuropsychologic functioning, electroencephalogram, and auditory threshold in depressed patients
Autore:
Loo, C; Sachdev, P; Esayed, H; McDarmont, B; Mitchell, P; Wilkinson, M; Parker, G; Gandevia, S;
Indirizzi:
Prince Wales Hosp, Dept Psychiat, Randwick, NSW 2031, Australia Prince Wales Hosp Randwick NSW Australia 2031 ndwick, NSW 2031, Australia Prince Wales Hosp, Inst Neuropsychiat, Randwick, NSW 2031, Australia Prince Wales Hosp Randwick NSW Australia 2031 ndwick, NSW 2031, Australia Prince Wales Hosp, Mood Disorders Unit, Randwick, NSW 2031, Australia Prince Wales Hosp Randwick NSW Australia 2031 ndwick, NSW 2031, Australia Prince Wales Hosp, Audiol Clin, Randwick, NSW 2031, Australia Prince WalesHosp Randwick NSW Australia 2031 ndwick, NSW 2031, Australia Prince Wales Med Res Inst, Sydney, NSW, Australia Prince Wales Med Res Inst Sydney NSW Australia t, Sydney, NSW, Australia Univ New S Wales, Fac Med, Sch Psychiat, Kensington, NSW 2033, Australia Univ New S Wales Kensington NSW Australia 2033 ngton, NSW 2033, Australia Univ New S Wales, Fac Med, Sch Med, Kensington, NSW 2033, Australia Univ New S Wales Kensington NSW Australia 2033 ngton, NSW 2033, Australia
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 7, volume: 49, anno: 2001,
pagine: 615 - 623
SICI:
0006-3223(20010401)49:7<615:EOA24C>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR DEPRESSION; SAFETY; MOOD;
Keywords:
transcranial magnetic stimulation; treatment; safety; neuropsychologic; hearing; EEG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Loo, C Prince Wales Hosp, Dept Psychiat, Cnr High & Avoca St, Randwick, NSW 2031,Australia Prince Wales Hosp Cnr High & Avoca St Randwick NSW Australia 2031 a
Citazione:
C. Loo et al., "Effects of a 2-to 4-week course of repetitive transcranial magnetic stimulation (rTMS) on neuropsychologic functioning, electroencephalogram, and auditory threshold in depressed patients", BIOL PSYCHI, 49(7), 2001, pp. 615-623

Abstract

Background: The safety of repetitive transcranial magnetic stimulation (rTMS) has only previously been formally studied in volunteers receiving a single session of stimulation or in al small number of depressed subjects receiving a 2-week treatment course. This study examined safety issues in depressed subjects receiving up to 4 weeks of rTMS. Efficacy results from this study have been previously reported. Methods: Eighteen subjects with DSM-IV major depression participated in a 2-week, parallel, double-blind, sham-controlled study of rTMS treatment. Twelve subjects then went on the receive 4 weeks active rTMS in an open follow-up. We examined the effects of rTMS on neuropsychologic function (up to 4weeks), auditory threshold (up to 6 weeks exposure to rTMS noise), and an electroencephalogram (after 2 weeks). Data were analyzed by repeated measures analysis. Results: There were trends for improvement in neuropsychologic performance, probably due to practice effects. No mean changes in auditory threshold occurred, but two patients showed mild high-frequency hearing loss after several weeks of rTMS. Electroencephalogram sin two patients one of whom had sham stimulation, showed minor abnormality. Conclusions: No significant mean deficits were demonstrated in this cohort. Overall, rTMS for up to 4 weeks is safe, but individual results suggest caution and the need for further investigation of the safety of several weeks of rTMS. Biol Psychiatry 2001;49:615-623 (C) 2001 Society of Biological Psychiatry.

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Documento generato il 03/04/20 alle ore 19:52:15