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Titolo:
Genetic differences in the tail-suspension test and its relationship to imipramine response among 11 inbred strains of mice
Autore:
Liu, XQ; Gershenfeld, HK;
Indirizzi:
Univ Texas, SW Med Ctr, Dept Psychiat, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 d Ctr, Dept Psychiat, Dallas, TX 75390 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 7, volume: 49, anno: 2001,
pagine: 575 - 581
SICI:
0006-3223(20010401)49:7<575:GDITTT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENERALIZED ANXIETY DISORDER; ANTIDEPRESSANT DRUGS; MOUSE STRAINS; ANIMAL-MODEL; DEPRESSION; RATS; SUSCEPTIBILITY; DESIPRAMINE; MUTAGENESIS; SEROTONIN;
Keywords:
behavioral despair; antidepressants; imipramine; inbred mice; tail suspension test; transgenic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Gershenfeld, HK Univ Texas, SW Med Ctr, Dept Psychiat, 5323 Harry Hines Blvd, Dallas, TX 75390 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75390 0 USA
Citazione:
X.Q. Liu e H.K. Gershenfeld, "Genetic differences in the tail-suspension test and its relationship to imipramine response among 11 inbred strains of mice", BIOL PSYCHI, 49(7), 2001, pp. 575-581

Abstract

Background: The tail suspension test (TST) is a simple screening test for the behavioral effects of antidepressants in rodents. This experiment investigated the interindividual differences in responses to stressful situations measured by duration of immobility in the TST and the effects of imipramine (30 mg/kg intraperitoneally) in reducing immobility among 11 inbred strains of mice. The 11 inbred strains were 129S6/SvEvTac, A/J, AKR/J, Balb/cJ,C3H/HeJ, C57BL/6J, DBA/2J, FVB/NJ, NMR1, SencarA/PtJ, and SWR/J. Methods: All mice underwent two trials of TST: 1) spontaneous, basal TST and 2) imipramine or saline TST. The duration of immobility was the trait measured during a 6-min test. Results: In the four strains tested, female mice had longer duration of immobility than male mice in basal TST duration of immobility. For male mice (n = 11 strains), significant strain differences in immobility duration were found for both basal TST and imipramine response TST, with heritability estimates of .31 and .60, respectively. Immobility duration for the DBA/2J, FVB/NJ, and NMRI strains were significantly reduced by imipramine, relativeto saline. Surprisingly, this reduction of immobility by imipramine was independent of the basal immobility. Conclusions: These results suggest that the responses on basal TST and theimipramine-mediated responses on TST are mediated by separate genetic pathways. Biol Psychiatry 2001;49:575-581 (C) 2001 Society of Biological Psychiatry.

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Documento generato il 31/03/20 alle ore 17:42:01