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Titolo:
Study on glutathionesulphonic acid as biodistribution promoter: Concomitant use effect on verapamil hydrochloride and tegafur
Autore:
Ohkawa, Y; Higashiyama, K; Sugaya, S; Asoh, T; Maeda, H; Sasaki, K; Nakayama, T;
Indirizzi:
Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan Okayama Univ Okayama Japan 7008530 harmaceut Sci, Okayama 7008530, Japan
Titolo Testata:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
fascicolo: 4, volume: 24, anno: 2001,
pagine: 378 - 384
SICI:
0918-6158(200104)24:4<378:SOGAAB>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRUG/CONJUGATED-METABOLITE INTERACTIONS; ACETAMINOPHEN SULFATE; P-GLYCOPROTEIN; RATS; PLASMA; BIOTRANSFORMATION; PHARMACOKINETICS; KINETICS; DRUG;
Keywords:
biodistribution promoter; concomitant use; drug/metabolite interaction; glutathionesulphonic acid; verapamil hydrochloride; tegafur;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Nakayama, T Okayama Univ, Fac Pharmaceut Sci, 1-1-1 Tsushima Naka, Okayama7008530, Japan Okayama Univ 1-1-1 Tsushima Naka Okayama Japan 7008530 Japan
Citazione:
Y. Ohkawa et al., "Study on glutathionesulphonic acid as biodistribution promoter: Concomitant use effect on verapamil hydrochloride and tegafur", BIOL PHAR B, 24(4), 2001, pp. 378-384

Abstract

The effect of glutathionesulphonic acid (N-(N-gamma -L-glutamyl-L-beta -sulphoalanylglycine, GSO(3H)), which is one of the minor metabolites of glutathione (GSH), on the pharmacokinetics of verapamil hydrochloride (verapamil. HCl) and tegafur was investigated in rats. CSO3H was concomitantly used as sodium salt (GSO(3)Na). No significant change by the concomitant use of GSO(3)Na was recognized inthe pharmacokinetics parameters of verapamil . HCl and tegafur, and plasmaelimination of both substances was not affected by GSO(3)Na. The tissue-to-plasma concentration ratio (K-p) of verapamil . HCl in the lung 5 min after its administration under concomitant use of GSO(3)Na rose significantly, however, this effect disappeared 120 min after administration. No significant change nas recognized in other organs. On the other hand, a significant difference of K-p of tegafur under a steady state concentration of GSO(3)Nawas not recognized in any organs. It seemed that the elevation of a lipid solubility (oil water partition coefficient) of verapamil . HCl by the concomitant use of GSO(3)Na was related to the increase of the K-p value of verapamil . HCI in the lung. The partition coefficient of GSO(3)Na itself decreased when it was used concomitantly with verapamil HCl.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 20:01:15