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Titolo:
L-glutamate suppresses astrocyte stellation induced by actin breakdown in culture
Autore:
Abe, K; Saito, H;
Indirizzi:
Univ Tokyo, Fac Pharmaceut Sci, Dept Chem Pharmacol, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 Dept Chem Pharmacol, Tokyo 1130033, Japan Hoshi Univ, Sch Pharm, Dept Pharmacol, Tokyo 1428501, Japan Hoshi Univ Tokyo Japan 1428501 arm, Dept Pharmacol, Tokyo 1428501, Japan
Titolo Testata:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
fascicolo: 4, volume: 24, anno: 2001,
pagine: 347 - 350
SICI:
0918-6158(200104)24:4<347:LSASIB>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT CORTICAL ASTROCYTES; BLOOD-BRAIN-BARRIER; PROTEIN-KINASE-C; STIMULATED STELLATION; ALZHEIMERS-DISEASE; REACTIVE GLIOSIS; TRANSPORTER; EXPRESSION; SHAPE; INDUCTION;
Keywords:
astrocyte; glutamate transporter; actin filaments; L-glutamate; morphology; culture;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Abe, K Univ Tokyo, Fac Pharmaceut Sci, Dept Chem Pharmacol, Tokyo 1130033,Japan Univ Tokyo Tokyo Japan 1130033 em Pharmacol, Tokyo 1130033, Japan
Citazione:
K. Abe e H. Saito, "L-glutamate suppresses astrocyte stellation induced by actin breakdown in culture", BIOL PHAR B, 24(4), 2001, pp. 347-350

Abstract

We have recently found that L-glutamate suppresses morphological changes of astrocytes induced by amyloid beta protein, adenosine 3',5'-cyclic monophosphate or phorbol ester in culture, To test the possibility that L-glutamate affects organization of the cytoskeleton, nle investigated its effect onmorphological changes induced by disruption of actin filaments with cytochalasin B, Cultured rat cortical astrocytes exhibited hat, polygonal morphology in the absence of stimulation, and changed into process-bearing stellate cells following treatment with cytochalasin B (50 muM). L-Glutamate strongly suppressed the stellation induced by cytochalasin B. The effect of L-glutamate was mimicked by D- and L-aspartate and transportable glutamate uptake inhibitors. These results suggest that glutamate transporter activity leads to cytoskeletal actin organization in astrocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:05:29