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Titolo:
Synthesis, characterization, and relaxivity of two linear Gd(DTPA)-polymerconjugates
Autore:
Duarte, MG; Gil, MH; Peters, JA; Colet, JM; Vander Elst, L; Muller, RN; Geraldes, CFGC;
Indirizzi:
Univ Coimbra, Fac Ciencias & Tecnol, Dept Bioquim, P-3001301 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3001301 uim, P-3001301 Coimbra, Portugal Univ Coimbra, Fac Ciencias & Tecnol, Dept Engn Quim, P-3001301 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3001301 uim, P-3001301 Coimbra, Portugal Delft Univ Technol, Lab Appl Organ Chem & Catalysis, NL-2600 AA Delft, Netherlands Delft Univ Technol Delft Netherlands NL-2600 AA 00 AA Delft, Netherlands Univ Mons, Fac Med, Dept Organ Chem, NMR Lab, B-7000 Mons, Belgium Univ Mons Mons Belgium B-7000 Organ Chem, NMR Lab, B-7000 Mons, Belgium Ctr Neurociencias, Coimbra, Portugal Ctr Neurociencias Coimbra PortugalCtr Neurociencias, Coimbra, Portugal
Titolo Testata:
BIOCONJUGATE CHEMISTRY
fascicolo: 2, volume: 12, anno: 2001,
pagine: 170 - 177
SICI:
1043-1802(200103/04)12:2<170:SCAROT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESONANCE CONTRAST AGENTS; PARAMAGNETIC PROPERTIES; GD3+-DIETHYLENETRIAMINEPENTAACETIC ACID; PHYSICOCHEMICAL CHARACTERIZATION; RELAXATION PROPERTIES; MOLECULAR-WEIGHT; GD-DTPA; RELAXOMETRY; COMPLEXES; CARRIERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Geraldes, CFGC Univ Coimbra, Fac Ciencias & Tecnol, Dept Bioquim, Apartado3126, P-3001301 Coimbra, Portugal Univ Coimbra Apartado 3126 Coimbra Portugal P-3001301 ugal
Citazione:
M.G. Duarte et al., "Synthesis, characterization, and relaxivity of two linear Gd(DTPA)-polymerconjugates", BIOCONJ CHE, 12(2), 2001, pp. 170-177

Abstract

Two linear polyamide conjugates of Gd(DTPA)(2-) were synthesized and characterized by high-resolution nuclear magnetic resonance (NMR) spectroscopy and size exclusion chromatography (SEC). DTPA was copolymerized with two different diamines, 1,6-hexanediamine and trans-1,4-cyclohexanediamine, yielding the polymers DTPA-HMD and DTPA-CHD, with low polydispersity. Their molecular flexibility in solution was studied using C-13 spin-lattice relaxationtime measurements, indicating that the cyclohexanediamine linking moiety of the DTPA-HMD polymer is more rigid than that of DTPA-CHD. The influence of the flexibility of the linking functionalities on the relaxivity of the Gd3+-DTPA-polymer conjugates was studied by water nuclear magnetic relaxation dispersion (NMRD). The relaxivity of the Gd(DTPA-CHD) polymer was only slightly higher than that of the Gd(DTPA-HMD) polymer, and only two times higher than the usual values for small Gd-DTPA-like chelates. The low relaxivities obtained for both polymers, much lower than expected from the polymer apparent molecular weights, result from their substantial residual flexibility, and also from a too long, nonoptimal, value of the inner-sphere water exchange rate. These polymeric compounds are also cleared very quickly fromthe blood of rats, indicating that they are of limited value as blood poolcontrast agents for MRA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:23:20