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Titolo:
Activation-dependent surface expression of LOX-1 in human platelets
Autore:
Chen, MY; Kakutani, M; Naruko, T; Ueda, M; Narumiya, S; Masaki, T; Sawamura, T;
Indirizzi:
Natl Cardiovasc Ctr, Res Inst, Osaka 5658565, Japan Natl Cardiovasc Ctr Osaka Japan 5658565 , Res Inst, Osaka 5658565, Japan Kyoto Univ, Fac Med, Dept Pharmacol, Kyoto 606, Japan Kyoto Univ Kyoto Japan 606 iv, Fac Med, Dept Pharmacol, Kyoto 606, Japan Osaka City Univ, Sch Med, Dept Pharmacol, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 Dept Pharmacol, Osaka 5458585, Japan Osaka City Gen Hosp, Dept Cardiol, Osaka 5340021, Japan Osaka City Gen Hosp Osaka Japan 5340021 pt Cardiol, Osaka 5340021, Japan Osaka Univ, Grad Sch Pharmaceut Sci, Dept Mol Pathophysiol, Osaka 5650871,Japan Osaka Univ Osaka Japan 5650871 ept Mol Pathophysiol, Osaka 5650871,Japan
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 1, volume: 282, anno: 2001,
pagine: 153 - 158
SICI:
0006-291X(20010323)282:1<153:ASEOLI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; HUMAN ATHEROSCLEROTIC LESIONS; ENDOTHELIAL-CELLS; BLOOD-PLATELETS; OXIDIZED LDL; REGULATED EXPRESSION; POTENTIAL ROLE; RECEPTOR-1; MACROPHAGES; GENE;
Keywords:
LOX-1; oxidized LDL; human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Sawamura, T Natl Cardiovasc Ctr, Res Inst, Osaka 5658565, Japan Natl Cardiovasc Ctr Osaka Japan 5658565 Osaka 5658565, Japan
Citazione:
M.Y. Chen et al., "Activation-dependent surface expression of LOX-1 in human platelets", BIOC BIOP R, 282(1), 2001, pp. 153-158

Abstract

Lectin-like oxidized LDL receptor-1 (LOX-1) was initially identified as anoxidized LDL receptor in aortic endothelial cells. Here we identified LOX-1 mRNA and protein in human platelets in addition to recent findings on theexpression in macrophages and smooth muscle cells. The presence of LOX-1 was further confirmed in the megakaryocytic cell lines. Flow cytometric analyses revealed that LOX-1 was exposed on the surface of platelets in an activation-dependent manner. Consistently, the activation-dependent binding of OxLDL to platelets was mostly inhibited by anti-LOX-1 antibody. Immunohistochemistry of the atherosclerotic plaque from a patient with unstable anginapectoris (UAP) revealed accumulation of LOX-1 protein at the site of thrombus, As LOX-1 recognizes and binds activated platelets, exposure of LOX-1 on activated platelets surface might assist thrombosis formation. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:22:39