Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Comparison of aortic and carotid baroreflex stimulus-response characteristics in humans
Autore:
Smith, SA; Querry, RG; Fadel, PJ; Weiss, MW; Olivencia-Yurvati, A; Shi, XR; Raven, PB;
Indirizzi:
Univ N Texas, Hlth Sci Ctr, Dept Integrat Physiol, Ft Worth, TX 76107 USA Univ N Texas Ft Worth TX USA 76107 tegrat Physiol, Ft Worth, TX 76107 USA Univ N Texas, Hlth Sci Ctr, Cardiovasc Res Inst, Ft Worth, TX 76107 USA Univ N Texas Ft Worth TX USA 76107 ovasc Res Inst, Ft Worth, TX 76107 USA
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 1-2, volume: 88, anno: 2001,
pagine: 74 - 85
SICI:
1566-0702(20010412)88:1-2<74:COAACB>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-RATE CONTROL; CARDIAC REFLEX; PRESSURE; EXERCISE; SINUS; BARORECEPTORS; REDUCTIONS; DEVICE; MEN;
Keywords:
baroreceptors; hypertension; hypotension; sodium nitroprusside; phenylephrine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, SA Univ N Texas, Hlth Sci Ctr, Dept Integrat Physiol, 3500 Camp Bowie Blvd, Ft Worth, TX 76107 USA Univ N Texas 3500 Camp Bowie Blvd Ft Worth TX USA 76107 6107 USA
Citazione:
S.A. Smith et al., "Comparison of aortic and carotid baroreflex stimulus-response characteristics in humans", AUTON NEURO, 88(1-2), 2001, pp. 74-85

Abstract

In order to characterize the stimulus-response relationships of the arterial, aortic, and carotid baroreflexes in mediating cardiac chronotropic function, we measured heart rate (HR) responses elicited by acute changes in mean arterial pressure (MAP) and carotid sinus pressure (CSP) in 11 healthy individuals. Arterial (aortic + carotid) baroreflex control of HR was quantified using ramped changes in MAP induced by bolus injection of phenylephrine (PE) and sodium nitroprusside (SN). To assess aortic-cardiac responses, neck pressure (NP) and suction (NS) were applied during PE and SN administration, respectively, to counter alterations in CSP thereby isolating the aortic baroreflex. Graded levels of NP and NS were delivered to the carotid sinus using a customized neck collar device to assess the carotid-cardiac baroreflex, independent of drug infusion. The operating characteristics of each reflex were determined from the logistic function of the elicited HR response to the induced change in MAP. The arterial pressures at which the threshold was located on the stimulus-response curves determined for the arterial, aortic and carotid baroreflexes were not significantly different (72 +/- 4, 67 +/- 3, and 72 +/- 4 mm Hg, respectively, P > 0.05). Similarly, the MAP at which the saturation of the reflex responses were elicited did not differ among the baroreflex arcs examined (98 +/- 3, 99 +/- 2, and 102 +/- 3mm Hg. respectively). These data suggest that the baroreceptor populationsstudied operate over the same range of arterial pressures. This finding indicates each baroreflex functions as both an important anti-hypotensive andanti-hypertensive mechanism. In addition, this investigation describes a model of aortic baroreflex function in normal healthy humans, which may prove useful in identifying the origin of baroreflex dysfunction in disease- and training-induced conditions. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:30:24