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Titolo:
Nociceptive stimulation increases NO synthase mRNA and vasopressin heteronuclearRNA in the rat paraventricular nucleus
Autore:
Kurose, T; Ueta, Y; Nomura, M; Yamaguchi, K; Nagata, S;
Indirizzi:
Univ Occupat & Environm Hlth, Inst Ind Ecol Sci, Dept Mental Hlth, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 8555, Japan Univ Occupat & Environm Hlth, Sch Med, Dept Physiol, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 8555, Japan Niigata Univ, Sch Med, Dept Physiol, Niigata 9518510, Japan Niigata Univ Niigata Japan 9518510 Dept Physiol, Niigata 9518510, Japan
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 1-2, volume: 88, anno: 2001,
pagine: 52 - 60
SICI:
1566-0702(20010412)88:1-2<52:NSINSM>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; CORTICOTROPIN-RELEASING HORMONE; PITUITARY-ADRENAL AXIS; IN-SITU HYBRIDIZATION; GENE-EXPRESSION; ARGININE-VASOPRESSIN; SUPRAOPTIC NUCLEI; MESSENGER-RNA; UP-REGULATION; FORMALIN TEST;
Keywords:
arginine vasopressin; formalin; hypothalamus; in situ hybridization; nitric oxide synthase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Kurose, T Univ Occupat & Environm Hlth, Inst Ind Ecol Sci, Dept Mental Hlth, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 n
Citazione:
T. Kurose et al., "Nociceptive stimulation increases NO synthase mRNA and vasopressin heteronuclearRNA in the rat paraventricular nucleus", AUTON NEURO, 88(1-2), 2001, pp. 52-60

Abstract

Nociceptive stimulation causes neuroendocrine responses such as arginine vasopressin (AVP) release and activation of the hypothalamo-pituitary-adrenal (HPA) axis. We examined the effects of nociceptive stimulation on the expression levels of neuronal nitric oxide synthase (nNOS) mRNA, heteronuclear(hn)RNA for AVP and AVP mRNA in the rat paraventricular nucleus (PVN) and supraoptic nucleus (SON). using in situ hybridization histochemistry. For nociceptive stimulation, formalin (5%) or saline was injected subcutaneously(s.c.) into the bilateral hind paws of rats. The expression of the nNOS gene in the PVN was significantly increased 2 and 6 h after s.c. injection offormalin in comparison with that in untreated and saline injected rats. The expression of the nNOS gene in the SON did not change in the untreated, saline- and formalin-injected rats. The AVP hnRNA in the PVN and SON was also significantly increased 15, 30 min and 2 h after s.c. injection of formalin, though AVP mRNA did not change at any time points that we studied. Plasma concentration of AVP was significantly increased 15 min after s.c. injection of formalin. These results suggest that NO in the PVN may be involved in nociceptive stimulation-induced neuroendocrine responses. (C) 2001 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 00:29:46