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Titolo:
Estrogen blocks the cardiovascular and autonomic changes following vagal stimulation in ovariectomized rats
Autore:
Saleh, TM; Saleh, MC; Connell, BJ;
Indirizzi:
Univ Prince Edward Isl, Atlantic Vet Coll, Dept Anat & Physiol, Charlottetown, PE C1A 4P3, Canada Univ Prince Edward Isl Charlottetown PE Canada C1A4P3 PE C1A 4P3, Canada
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 1-2, volume: 88, anno: 2001,
pagine: 25 - 35
SICI:
1566-0702(20010412)88:1-2<25:EBTCAA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
VISCERAL AFFERENT ACTIVATION; SEX-RELATED DIFFERENCES; BAROREFLEX SENSITIVITY; REPLACEMENT THERAPY; POSTMENOPAUSAL WOMEN; PURE ANTIESTROGEN; NERVOUS-SYSTEM; DEATH; 17-BETA-ESTRADIOL; MODULATION;
Keywords:
visceral afferents; sympathetic; parasympathetic; ICI 182, 780; female;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Saleh, TM Univ Prince Edward Isl, Atlantic Vet Coll, Dept Anat & Physiol, Charlottetown, PE C1A 4P3, Canada Univ Prince Edward Isl Charlottetown PE Canada C1A 4P3 , Canada
Citazione:
T.M. Saleh et al., "Estrogen blocks the cardiovascular and autonomic changes following vagal stimulation in ovariectomized rats", AUTON NEURO, 88(1-2), 2001, pp. 25-35

Abstract

The current investigation examines the effect of acute and chronic estrogen administration on baroreflex sensitivity and autonomic tone following 2 hof vagal afferent stimulation in ovariectomized female rats. Female Sprague-Dawley rats were ovariectomized and supplemented daily for 7 days with either estrogen (OVX-E-2; 0.5 mug/kg; s.c.) or saline (OVX-S: 0.9%: s.c.). Onthe 8th day the animals were anaesthetized (sodium thiobutabarbitol; 100 mg/kg) and instrumented for recording blood pressure, heart rate and efferent vagal and renal nerve activities. The baroreflex was evoked using intravenous injection of various doses of phenylephrine hydrochloride (0.025. 0.05, 0.1 mg/kg). Electrical stimulation of vagal afferents for 2 h produces autonomic imbalance characterized by sympathoexcitation and parasympathetic withdrawal. This protocol of vagal stimulation produced a significant increase in renal nerve activity (from 20 +/- 6 to 140 +/- 20 spikes/2 s) and decreases in both vagal nerve activity (from 22 +/- 3 to 10 +/- 2 spikes/2 s) and baroreflex sensitivity (from 0.55 +/- 0.05 to 0.3 +/- 0.05) in OVX-S female rats. However, vagal stimulation had no effect on baroreflex sensitivity or autonomic nerve activities in OVX-E-2 rats. Administration of a single, bolus dose of estrogen (1 X 10(-2) mg/kg) to OVX-S rats immediately prior to termination of vagal stimulation blocked the changes in autonomic nerve activities and baroreflex sensitivity previously observed. These results suggest that both chronic and acute estrogen supplementation may provide resistance to the autonomic disturbances associated with visceral afferent activation. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 13:45:22