Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis
Autore:
Chabaud, M; Lubberts, E; Joosten, L; van den Berg, W; Miossec, P;
Indirizzi:
Hop Edouard Herriot, Dept Immunol, Clin Immunol Unit, F-69437 Lyon 03, France Hop Edouard Herriot Lyon France 03 Immunol Unit, F-69437 Lyon 03, France Fac Med Laennec, INSERM, U403, Lyon, France Fac Med Laennec Lyon FranceFac Med Laennec, INSERM, U403, Lyon, France Hop Edouard Herriot, Dept Rheumatol, F-69437 Lyon, France Hop Edouard Herriot Lyon France F-69437 Rheumatol, F-69437 Lyon, France Univ Nijmegen Hosp, Dept Rheumatol, Rheumatol Res Lab, NL-6500 HB Nijmegen, Netherlands Univ Nijmegen Hosp Nijmegen Netherlands NL-6500 HB Nijmegen, Netherlands
Titolo Testata:
ARTHRITIS RESEARCH
fascicolo: 3, volume: 3, anno: 2001,
pagine: 168 - 177
SICI:
1465-9913(2001)3:3<168:IDFJBA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; OSTEOCLAST DIFFERENTIATION FACTOR; T-CELL PRODUCTION; NF-KAPPA-B; IN-VITRO; PROINFLAMMATORY CYTOKINES; OSTEOPROTEGERIN LIGAND; RECEPTOR ANTAGONIST; TH2 CELLS; TNF-ALPHA;
Keywords:
bone; cartilage; degradation; IL-17; rheumatoid arthritis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Miossec, P Hop Edouard Herriot, Dept Immunol, Clin Immunol Unit, F-69437 Lyon 03, France Hop Edouard Herriot Lyon France 03 t, F-69437 Lyon 03, France
Citazione:
M. Chabaud et al., "IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis", ARTHRITIS R, 3(3), 2001, pp. 168-177

Abstract

The origin and role of IL-17, a T-cell derived cytokine, in cartilage and bone destruction during rheumatoid arthritis (RA) remain to be clarified. In human ex vivo models, addition of IL-17 enhanced IL-6 production and collagen destruction, and inhibited collagen synthesis by RA synovium explants. On mouse cartilage, IL-17 enhanced cartilage proteoglycan loss and inhibited its synthesis. On human RA bone explants, IL-17 also increased bone resorption and decreased formation. Addition of IL-1 in these conditions increased the effect of IL-17. Blocking of bone-derived endogenous IL-17 with specific inhibitors resulted in a protective inhibition of bone destruction. Conversely, intra-articular administration of IL-17 into a normal mouse joint induced cartilage degradation. In conclusion, the contribution of IL-17 derived from synovium and bone marrow T cells to joint destruction suggests the control of IL-17 for the treatment of RA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 03:49:39