Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Time-resolved FT-IR spectroscopy of chemical reactions in solution by fastdiffusion-based mixing in a micromachined flow cell
Autore:
Hinsmann, P; Haberkorn, M; Frank, J; Svasek, P; Harasek, M; Lendl, B;
Indirizzi:
Vienna Univ Technol, Inst Analyt Chem, A-1060 Vienna, Austria Vienna Univ Technol Vienna Austria A-1060 t Chem, A-1060 Vienna, Austria Vienna Univ Technol, Inst Chem Phys, A-1060 Vienna, Austria Vienna Univ Technol Vienna Austria A-1060 m Phys, A-1060 Vienna, Austria Vienna Univ Technol, Inst Ind Elect & Mat Sci, Ludwig Boltzmann Inst Biomed Microtechnol, A-1040 Vienna, Austria Vienna Univ Technol Vienna AustriaA-1040 echnol, A-1040 Vienna, Austria Inst Chem Engn Fuel & Environm Technol, A-1060 Vienna, Austria Inst Chem Engn Fuel & Environm Technol Vienna Austria A-1060 na, Austria
Titolo Testata:
APPLIED SPECTROSCOPY
fascicolo: 3, volume: 55, anno: 2001,
pagine: 241 - 251
SICI:
0003-7028(200103)55:3<241:TFSOCR>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSITION-METAL COMPLEXES; INFRARED-SPECTROSCOPY; AQUEOUS-SOLUTION; DIFFERENCE SPECTROSCOPY; REACTION-MECHANISMS; CURVE RESOLUTION; PROTEIN FUNCTION; RIBONUCLEASE-A; EXCITED-STATES; KINETIC DATA;
Keywords:
time-resolved FT-IR spectroscopy; rapid mixing; diffusion; microfluidics; chemical reactions; CFD simulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Lendl, B Vienna Univ Technol, Inst Analyt Chem, Getreidermarkt 9-151, A-1060 Vienna, Austria Vienna Univ Technol Getreidermarkt 9-151 Vienna AustriaA-1060 a
Citazione:
P. Hinsmann et al., "Time-resolved FT-IR spectroscopy of chemical reactions in solution by fastdiffusion-based mixing in a micromachined flow cell", APPL SPECTR, 55(3), 2001, pp. 241-251

Abstract

A new concept for the study of chemical reactions in solution by time-resolved Fourier transform infrared spectroscopy (TR/FT-IR) is presented. The key element of this concept is a micromachined mixing unit for fast and highly reproducible diffusion-based mixing that is incorporated in a flow cell for transmission measurements and operated in the stopped-dow mode. The mixing unit achieves multilamination of two liquid streamlines inside the flowcell, When the flow in both feeding channels is maintained, there is almost no mixing of the liquids, because of the short residence time inside the mixer, hence allowing for the recording of a reference spectrum of the reactants prior to reaction. When the flow is stopped hy rapid switching of a dedicated injection valve, highly reproducible diffusion-controlled mixing takes place inside the flow cell so that spectral changes induced by the reaction under investigation can be directly followed. The total volume required for one experiment is similar to5 muL, and mixing times achieved so far are in the millisecond range. Factors governing time resolution in this newconcept are the time required to stop the flow, the spacing of the individual streamlines, the diffusion coefficients of the reactants involved, and the signal strength of the spectral changes induced by the reaction under study. In this paper, the possibilities and limitations of the new concept are studied with the use of three model reactions, which are an acid-base neutralization reaction, the addition of sulfite to formaldehyde, and the basic hydrolysis of methyl monochloroacetate, In addition, the complete mixingprocess in the system was studied by computational fluid dynamics (CFD) simulations, which provided valuable insights into details of the mixing process itself as well as confirming the experimental results obtained.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 10:45:51