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Titolo:
Advanced colorectal cancer in elderly patients: Tolerance and efficacy of lencovorin and fluorouracil bolus plus continuous infusion
Autore:
Mattioli, R; Lippe, P; Recchia, F; Massacesi, C; Imperatori, L; De Filippis, S; Rosselli, M; Gattafoni, P; Casadei, V; Consales, D;
Indirizzi:
S Croce Hosp, Med Oncol Unit, I-61032 Fano, Italy S Croce Hosp Fano Italy I-61032 osp, Med Oncol Unit, I-61032 Fano, Italy Civilian Hosp, Dept Med Oncol, I-67051 Avezzano, Italy Civilian Hosp Avezzano Italy I-67051 Med Oncol, I-67051 Avezzano, Italy Sestili Hosp, Dept Med, INRCA, IRCCS, I-60100 Ancona, Italy Sestili Hosp Ancona Italy I-60100 d, INRCA, IRCCS, I-60100 Ancona, Italy Torrette Hosp, Dept Med Oncol, I-60020 Ancona, Italy Torrette Hosp Ancona Italy I-60020 Dept Med Oncol, I-60020 Ancona, Italy
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 1A, volume: 21, anno: 2001,
pagine: 489 - 492
SICI:
0250-7005(200101/02)21:1A<489:ACCIEP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOMIZED TRIAL; SUPPORTIVE CARE; OLDER; CHEMOTHERAPY; SURVIVAL;
Keywords:
advanced colorectal cancer; elderly patients; 5-fluorouracil; leucovorin; bolus; continuous infusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Lippe, P S Croce Hosp, Med Oncol Unit, I-61032 Fano, Italy S Croce Hosp Fano Italy I-61032 Oncol Unit, I-61032 Fano, Italy
Citazione:
R. Mattioli et al., "Advanced colorectal cancer in elderly patients: Tolerance and efficacy of lencovorin and fluorouracil bolus plus continuous infusion", ANTICANC R, 21(1A), 2001, pp. 489-492

Abstract

Background. Colorectal cancer (CRC) incidence increases sharply with age. In this study we assessed activity, toxicity and both the activity of dailyliving (ADL) and instrumental activity of daily living (IADL) of the De Gramont schedule in a series of advanced CRC patients aged greater than or equal to 70 years. Patients and methods. Sixty-two previously untreated advanced CRC patients entered the study. Median age was 75 (range 70-88). Results. 447 courses were delivered. All of the 62 patients were evaluable for toxicity, 55 for response and ADL-IADL indexes. We recorded 2 complete and 9 partial responses, for an overall response rate of 20%. ADL and IADL indexes improved in 33%, remained stable in 49% and worsened in 18% of evaluable patients. Treatment was very well-tolerated with no serious hematological or non-hematological toxicities. Conclusions. The De Gramont schedule was very well tolerated in advanced CRC elderly patients, although our work couldl not confirm the original reported activity ADL and IADL indexes improvedor remained stable in 82% of evaluable patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:26:43