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Titolo:
Bax protein expression in colorectal cancer: Association with p53, bcl-2 and patterns of relapse
Autore:
Giatromanolaki, A; Sivridis, E; Stathopoulos, GP; Fountzilas, G; Kalofonos, HP; Tsamandas, A; Vrettou, E; Scopa, C; Polychronidis, A; Simopoulos, K; Koukourakis, MI;
Indirizzi:
Democritus Univ Thrace, Dept Pathol, Alexandroupolis 68100, Greece Democritus Univ Thrace Alexandroupolis Greece 68100 upolis 68100, Greece Democritus Univ Thrace, Dept Surg, Alexandroupolis 68100, Greece Democritus Univ Thrace Alexandroupolis Greece 68100 upolis 68100, Greece Univ Athens, Hippokratio Gen Hosp, Dept Oncol, GR-10679 Athens, Greece Univ Athens Athens Greece GR-10679 , Dept Oncol, GR-10679 Athens, Greece Univ Athens, Hippokratio Gen Hosp, Dept Pathol, GR-10679 Athens, Greece Univ Athens Athens Greece GR-10679 Dept Pathol, GR-10679 Athens, Greece Aristotelian Univ Salonika, Dept Oncol, GR-54006 Salonika, Greece Aristotelian Univ Salonika Salonika Greece GR-54006 006 Salonika, Greece Aristotelian Univ Salonika, Dept Pathol, GR-54006 Salonika, Greece Aristotelian Univ Salonika Salonika Greece GR-54006 006 Salonika, Greece Univ Hosp Patras, Dept Oncol, Patras, Greece Univ Hosp Patras Patras Greece Hosp Patras, Dept Oncol, Patras, Greece Univ Hosp Patras, Dept Pathol, Patras, Greece Univ Hosp Patras Patras Greece Hosp Patras, Dept Pathol, Patras, Greece Univ Thessalia, Dept Radiotherapy & Oncol, Volos, Greece Univ Thessalia Volos Greece a, Dept Radiotherapy & Oncol, Volos, Greece
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 1A, volume: 21, anno: 2001,
pagine: 253 - 259
SICI:
0250-7005(200101/02)21:1A<253:BPEICC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; PROGNOSTIC-SIGNIFICANCE; INDUCED APOPTOSIS; DNA-REPAIR; CARCINOMAS; GENE; MUTATIONS; ENDONUCLEASE; ACTIVATOR; INDUCTION;
Keywords:
colorectal cancer; bax; p53; bcl-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Giatromanolaki, A Democritus Univ Thrace, Gen Hosp Alexandroupolis, Dept Pathol, POB 12, Alexandroupolis 68100, Greece Democritus Univ Thrace POB 12 Alexandroupolis Greece 68100
Citazione:
A. Giatromanolaki et al., "Bax protein expression in colorectal cancer: Association with p53, bcl-2 and patterns of relapse", ANTICANC R, 21(1A), 2001, pp. 253-259

Abstract

This study evaluated the frequency and the prognostic significance of bax,bcl-2 and p53 proteins in stage B and C adenocarcinomas of the colon and rectum. Paraffin-embedded specimens from 268 patients with colorectal adenocarcinomas, treated with surgery, were assessed; of these 160 cases wet-e Duke's stage B and 108 cases were Duke's stage C disease. Adjuvant chemotherapy was given to all stage C and to 108 out of 160 stage B cancer patients, while those having rectal malignancy also received pelvic radiotherapy. Duke's stage B patients were treated either with surgery alone or with surgeryand radiotherapy. The follow-up period at the time of analysis ranged from12-72 months (median 32 months). Immunohistochemical expression of bax, bcl-2 and mutant p53 proteins was detected with a frequency of 42%, 37% and 48%, respectively. However, the expression was strong only in 17% of tumours, on average. A strong bcl-2 expression was significantly associated with astrong bax expression (p < 0.0001) and with absence of p53 nuclear accumulation (p < 0.005). There was, however; no correlation between box and p53 proteins. Furthermore, bcl-2 expression was significantly more frequently grade 1 and 2 adenocarcinomas compared to grade 3 disease (p = 0.01). In stage B (but not C) adenocarcinomas, bax expression was directly associated with higher risk of local relapse (p = 0.04). By contrast, cases with p53 nuclear accumulation, when they had received adjuvant radiotherapy, Mia e significantly associated with a lower incidence of local relapse (p = 0.01) but a higher rate of distant metastasis (p = 0.06). Multivariate analysis for disease free and overall survival showed that bax expression and high Duke'sstage were independent prognostic parameters associated with an unfavourable outcome (p = 0.009 and p = 0.0001, respectively). It was concluded that the immunohistochemical expression of bax is a marker of poor prognosis andof a higher risk of local relapse in patients with colorectal adenocarcinomas. p53 nuclear accumulation is associated with a better local control following radiotherapy and with a metastatic phenotype. The development of novel monoclonal antibodies recognising specifically the mutated versus the wild type form of proteins would apparently improve the prognostic and predictive value of the immunohistochemically detected apoptotic proteins.

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Documento generato il 12/07/20 alle ore 13:20:45