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Titolo:
Zolpidem for antipsychatic-induced parkinsonism
Autore:
Farver, DK; Khan, MH;
Indirizzi:
S Dakota State Univ, Coll Pharm, S Dakota Human Serv Ctr, Yankton, SD 57078 USA S Dakota State Univ Yankton SD USA 57078 Serv Ctr, Yankton, SD 57078 USA
Titolo Testata:
ANNALS OF PHARMACOTHERAPY
fascicolo: 4, volume: 35, anno: 2001,
pagine: 435 - 437
SICI:
1060-0280(200104)35:4<435:ZFAP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TARDIVE-DYSKINESIA; DISEASE; CLOZAPINE; TREMOR; CORTEX;
Keywords:
antipsychotic-induced parkinsonism; zolpidem;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Farver, DK S Dakota State Univ, Coll Pharm, S Dakota Human Serv Ctr, POB 76, Yankton,SD 57078 USA S Dakota State Univ POB 76 Yankton SD USA 57078 on,SD 57078 USA
Citazione:
D.K. Farver e M.H. Khan, "Zolpidem for antipsychatic-induced parkinsonism", ANN PHARMAC, 35(4), 2001, pp. 435-437

Abstract

OBJECTIVE: TO report a case of antipsychotic-induced parkinsonism that wasmanaged with zolpidem. CASE SUMMARY: A 34-year-old white man who had had antipsychotic-induced parkinsonism with symptoms of repetitive persistent gross tremors of the hands for numerous years was unresponsive to traditional antiparkinsonian medications. With the initiation of zolpidem 10 mg four times daily, the tremorsdecreased significantly. DISCUSSION: The use of zolpidem for antipsychotic-induced parkinsonian hand tremors in this patient was based on the severity of the symptoms and thelack of response to several trials of traditional medications. When zolpidem was started at 10 mg four times a day, the motor examination score on the Unified Parkinson's Disease Rating Scale decreased from 29 at baseline toa score of 9 after one month of use. After four months of zolpidem use, the patient's mental status decompensated, and clozapine was initiated. As the patient experienced excessive sedation, zolpidem was discontinued while clozapine was maintained to help with the psychosis and, potentially, the tremors. The tremors reemerged with a motor examination score of 30. Zolpidemwas reinitiated at 5 mg four times daily, and the patient's tremors have been stable for two years. CONCLUSIONS: Further investigation is needed to study the use of nontraditional medications in patients requiring antipsychotic medications who have refractory parkinsonian symptoms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 22:40:05