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Titolo:
Soluble interleukin-2 receptor and interleukin-4 in sera of asthmatic children before and after a prednisolone course
Autore:
Tang, RB; Chen, SJ;
Indirizzi:
Vet Gen Hosp, Dept Pediat, Taipei 11217, Taiwan Vet Gen Hosp Taipei Taiwan 11217 Hosp, Dept Pediat, Taipei 11217, Taiwan Natl Yang Ming Univ, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 Yang Ming Univ, Taipei 112, Taiwan
Titolo Testata:
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
fascicolo: 3, volume: 86, anno: 2001,
pagine: 314 - 317
SICI:
1081-1206(200103)86:3<314:SIRAII>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTE-T ACTIVATION; BRONCHOALVEOLAR LAVAGE; INTERFERON-GAMMA; IL-2 RECEPTOR; ALLERGIC RHINITIS; PERIPHERAL-BLOOD; ATOPIC ASTHMA; IGE SYNTHESIS; CELLS; HYPOSENSITIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Tang, RB Vet Gen Hosp, Dept Pediat, 201,Sec 2,Shih Pai Rd, Taipei 11217, Taiwan Vet Gen Hosp 201,Sec 2,Shih Pai Rd Taipei Taiwan 11217 7, Taiwan
Citazione:
R.B. Tang e S.J. Chen, "Soluble interleukin-2 receptor and interleukin-4 in sera of asthmatic children before and after a prednisolone course", ANN ALLER A, 86(3), 2001, pp. 314-317

Abstract

Background: Cytokine-mediated interactions among inflammatory cells may play a role in the pathogenesis of bronchial asthma. Objective: To understand the role of soluble interleukin-2 receptor (sIL-2R) and interleukin-4 (IL-4) in the disease activity of acute asthma, changes in serum concentrations of sIL-2R and IL-4 elaborated by activated T-lymphocyte before and after prednisolone therapy with clinical improvement weredetermined in the present study. Methods: Circulating levels of sIL-2R and IL-4 in sera from 15 normal control subjects and in sera from 20 allergic asthmatic children with acute exacerbation and in a stable condition were determined by using commercially available ELISA kits. Results: The mean concentration of serum sIL-2R was significantly higher in acute exacerbation than in children with stable asthma (368.9 +/- 395.4 pg/mL vs 291.2 +/- 361.0 pg/mL; P < .01) or in control subjects (124.6 +/- 17.8 pg/mL; P < .001). The mean concentration of serum IL-4 was higher in acute exacerbation (5.82 +/- 1.10 pg/mL) and in stable asthmatic patients (6.73 +/- 2.83 pg/mL) versus control group subjects (5.54 +/- 1.20 pg/mL). However, the difference was not statistically significant among the three study groups. Conclusions: This study provides further evidence that changes in serum IL-2R may serve as an objective indicator for clinical outcome of allergic asthmatic patients.

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Documento generato il 10/04/20 alle ore 02:41:19