Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Airway responses to a diluent used in the methacholine challenge test
Autore:
Wanger, JS; Ikle, DN; Irvin, CG;
Indirizzi:
Pharmaceut Res Associates Inc, Lenexa, KS USA Pharmaceut Res Associates Inc Lenexa KS USA sociates Inc, Lenexa, KS USA City Hope Natl Med Ctr, Duarte, CA 91010 USA City Hope Natl Med Ctr Duarte CA USA 91010 Med Ctr, Duarte, CA 91010 USA Natl Jewish Med & Res Ctr, Denver, CO USA Natl Jewish Med & Res Ctr Denver CO USA sh Med & Res Ctr, Denver, CO USA Univ Vermont, Burlington, VT USA Univ Vermont Burlington VT USAUniv Vermont, Burlington, VT USA
Titolo Testata:
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
fascicolo: 3, volume: 86, anno: 2001,
pagine: 277 - 282
SICI:
1081-1206(200103)86:3<277:ARTADU>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHALATION CHALLENGE; INHALED HISTAMINE; BRONCHIAL RESPONSIVENESS; REACTIVITY; ASTHMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Wanger, JS PRA Int, 16300 Coll Blvd, Lenexa, KS 66219 USA PRA Int 16300 Coll Blvd Lenexa KS USA 66219 enexa, KS 66219 USA
Citazione:
J.S. Wanger et al., "Airway responses to a diluent used in the methacholine challenge test", ANN ALLER A, 86(3), 2001, pp. 277-282

Abstract

Background: Inhalation of diluent is often used in performing methacholinechallenge tests, but its elimination has been suggested because marked falls in FEV1 after diluent inhalation have not been documented and performingthis step is time-consuming. Objective: We investigated the frequency and magnitude of response to the inhalation of diluent, and if there were any systematic effects in determining the PC20 using the baseline and postdiluent spirometric measurements. Methods: All methacholine challenges performed during a 6-year period (N =3,902) were reviewed retrospectively. Results: The maximum increase and decrease in FEV1 and FVC from baseline were 56.3% and -41.4%, respectively, and 61.7% and -40.3%, respectively. Themean absolute changes from baseline in FEV1 and FVC were -0.018 L and -0.026 L, respectively. There was a highly significant correlation (r(2) = 0.96; P < .0001) between the PC20 baseline and PC20 postdiluent values, and a mean difference of 0.041 mg/mL (P < .0001), with the PC20 postdiluent being higher. Conclusions: These data do not provide strong evidence to support either using or eliminating the diluent stage. It is clear that there are frequent and sometimes large changes in FVC and FEV1 after the inhalation of diluentcontaining phenol and sodium bicarbonate buffer. If a laboratory intends to report changes in airway function qualitatively (ie, positive or negative), the diluent stage may not be necessary. However, if a laboratory intendsto report bronchial challenge data from inhaling methacholine in a quantitative fashion and report a continuous variable such as PC20, a diluent stage is recommended.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 10:35:24