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Titolo:
Magnetic resonance spectroscopy of the human brain
Autore:
Ross, B; Bluml, S;
Indirizzi:
Huntington Med Res Inst, Clin Magnet Resonance Spect Unit, Pasadena, CA 91105 USA Huntington Med Res Inst Pasadena CA USA 91105 nit, Pasadena, CA 91105 USA Univ So Calif, Sch Med, Los Angeles, CA USA Univ So Calif Los Angeles CA USA So Calif, Sch Med, Los Angeles, CA USA CALTECH, Pasadena, CA 91125 USA CALTECH Pasadena CA USA 91125CALTECH, Pasadena, CA 91125 USA Rudi Schulte Res Inst, Santa Barbara, CA USA Rudi Schulte Res Inst Santa Barbara CA USA s Inst, Santa Barbara, CA USA
Titolo Testata:
ANATOMICAL RECORD
fascicolo: 2, volume: 265, anno: 2001,
pagine: 54 - 84
SICI:
0003-276X(20010415)265:2<54:MRSOTH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTON NMR-SPECTROSCOPY; H-1 MR SPECTROSCOPY; CHRONIC HEPATIC-ENCEPHALOPATHY; LOCALIZED H-1-NMR SPECTRA; IN-VIVO; METABOLITE CONCENTRATIONS; WATER SUPPRESSION; P-31 NMR; ABSOLUTE QUANTITATION; CEREBRAL METABOLITES;
Keywords:
biomedical imaging; magnetic resonance imaging; MRI; MRS; spectroscopy; neurochemistry; brain disease; N-acetyl aspartate; myelination; Canavan disease; Huntington disease; Alzheimer disease;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Ross, B Huntington Med Res Inst, Clin Magnet Resonance Spect Unit, 660 S Fair OaksAve, Pasadena, CA 91105 USA Huntington Med Res Inst 660 S Fair OaksAve Pasadena CA USA 91105
Citazione:
B. Ross e S. Bluml, "Magnetic resonance spectroscopy of the human brain", ANAT REC, 265(2), 2001, pp. 54-84

Abstract

Magnetic resonance (MR; synonymous with NMR = nuclear magnetic resonance) is a universal physical technique best known for non-invasive detection andanatomical mapping of water protons (H). MR-spectroscopy (MRS) records protons from tissue chemicals other than water, intrinsic phosphorus containing metabolites, sodium, potassium, carbon, nitrogen, and fluorine, MRS is therefore an imaging technique with the potential to record human and animal biochemistry in vivo. As a result of wide availability of MRI equipment in research laboratories and hospitals, MRS is a serious competitor with PET to define normal body composition and its perturbation by pharmacological and pathological events. This article describes practical aspects of in vivo MRS with particular emphasis on the brain, where novel metabolites have been described. A survey of these new aspects of neurochemistry emphasize their practical utility as neuronal and axonal markers, measures of energy status, membrane constituents, and osmolytes, as well as some xenobiotics, suchas alcohol. The concept of multinuclear in vivo MRS is illustrated by diagnosis and therapeutic monitoring of several human brain disorders. Althoughthese methods are currently most frequently encountered in human studies, as well as with transgenic and knockout mouse models, MRS adds a new dimension to anatomic and histopathologic descriptions. Anat Rec (New Anat) 265:54-84, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 18:59:00