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Titolo:
Infusion of a combination of propofol and medetomidine for long-term anesthesia in ponies
Autore:
Bettschart-Wolfensberger, R; Freeman, SL; Jaggin-Schmucker, N; Clarke, KW;
Indirizzi:
Univ Zurich, Dept Anaesthesia, Vet Surg Clin, Zurich, Switzerland Univ Zurich Zurich Switzerland esia, Vet Surg Clin, Zurich, Switzerland Univ London, Univ London Royal Vet Coll, Dept Farm Anim & Equine Med & Surg, Hatfield, Herts, England Univ London Hatfield Herts England Med & Surg, Hatfield, Herts, England Univ Bern, Clin Horses, Bern, Switzerland Univ Bern Bern SwitzerlandUniv Bern, Clin Horses, Bern, Switzerland
Titolo Testata:
AMERICAN JOURNAL OF VETERINARY RESEARCH
fascicolo: 4, volume: 62, anno: 2001,
pagine: 500 - 507
SICI:
0002-9645(200104)62:4<500:IOACOP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOTAL INTRAVENOUS ANESTHESIA; KETAMINE; DOGS; HORSES; CARDIOPULMONARY; DETOMIDINE; HALOTHANE; ALTHESIN; AGONIST; TIME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Bettschart-Wolfensberger, R Univ Zurich, Dept Anaesthesia, Vet Surg Clin, Zurich, Switzerland Univ Zurich Zurich Switzerland Switzerland
Citazione:
R. Bettschart-Wolfensberger et al., "Infusion of a combination of propofol and medetomidine for long-term anesthesia in ponies", AM J VET RE, 62(4), 2001, pp. 500-507

Abstract

Objective-To determine the minimal infusion rate of propofol in combination with medetomidine for longterm anesthesia in ponies and the effects of atipamezole on recovery. Animals-12 ponies. Procedure-Ponies were sedated with medetomidine (7 mug/kg of body weight, IV). Ten minutes later, anesthesia was induced with propofol (2 mg/kg, IV). Anesthesia was maintained for 4 hours, using an infusion of medetomidine 13.5 mug/kg per hour, IV) and propofol at a rate sufficient to prevent ponies from moving after electrical stimulation. Arterial blood pressures and blood gas analysis, heart rates, and respiratory rates were monitored. For recovery, 6 ponies were given atipamezole (60 mug/kg, IV). Induction and recovery were scored. Results-Minimal propofol infusion rates ranged from 0.06 to 0.1 mg/kg per min. Mean arterial blood pressure was stable (range, 74 to 86 mm Hg), and heart rate (34 to 51 beats/min) had minimal variations. Variable breathing patterns were observed. Mean Pao(2) (range, 116 to 146 mm Hg) and mean Paco(2) (range, 48 to 51 mm Hg) did not change significantly with time, but hypoxemia was evident in some ponies (minimal Pao2, 47 mm Hg). Recovery was fast and uneventful with and without atipamezole (completed in 20.2 and 20.9 minutes, respectively). Conclusions and Clinical Relevance-Infusion of a combination of medetomidine and propofol was suitable for prolonged anesthesia in ponies. Recovery was rapid and uneventful. A combination of propofol and medetomidine may prove suitable for long-term anesthesia in horses. Monitoring of blood gases is essential because of potential hypoxemia.

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Documento generato il 12/08/20 alle ore 20:52:50