Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effect of water deprivation and hypertonic saline infusion on urinary AQP2excretion in healthy humans
Autore:
Pedersen, RS; Bentzen, H; Bech, JN; Pedersen, B;
Indirizzi:
Holstebro Hosp, Dept Med, DK-7500 Holstebro, Denmark Holstebro Hosp Holstebro Denmark DK-7500 Med, DK-7500 Holstebro, Denmark
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
fascicolo: 5, volume: 280, anno: 2001,
pagine: F860 - F867
SICI:
0363-6127(200105)280:5<F860:EOWDAH>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLLECTING DUCT; RAT-KIDNEY; NATRIURETIC-PEPTIDE; RENAL AQUAPORINS; ANGIOTENSIN-II; HUMAN PLASMA; VASOPRESSIN; EXPRESSION; CHANNEL; HYPERTENSION;
Keywords:
arginine vasopressin; healthy subjects; urinary output; aquaporin-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Pedersen, RS Holstebro Hosp, Dept Med, DK-7500 Holstebro, Denmark Holstebro Hosp Holstebro Denmark DK-7500 Holstebro, Denmark
Citazione:
R.S. Pedersen et al., "Effect of water deprivation and hypertonic saline infusion on urinary AQP2excretion in healthy humans", AM J P-REN, 280(5), 2001, pp. F860-F867

Abstract

Arginine vasopressin (AVP) mediates water transport in the renal collecting ducts by forming water channels of aquaporin-2 (AQP2) in the apical plasma membrane. AQP2 is excreted in human urine. We wanted to test the hypothesis that urinary excretion of AQP2 (u-AQP2) reflects the effect of AVP on the renal collecting ducts during water deprivation and hypertonic saline infusion in healthy subjects. Fifteen healthy subjects underwent a 24-h periodof fluid restriction. Urine and blood samples were collected at timed intervals. Fifteen healthy subjects were given 7 ml/kg 3% hypertonic saline infusion for 30 min. Urine and blood samples were collected at timed intervals. During fluid restriction, the u-AQP2 rate increased from 3.9 (25th percentile: 3.1; 75th percentile: 5.2) to 7.6 (5.9-9.1; P< 0.001) ng/min, and theplasma AVP (p-AVP) level increased from 0.5 (0.4-0.6) to 3 (1.7-3.3) pmol/l. There was a positive correlation between the maximum change in u-AQP2 rate and the maximum change in p-AVP (r = 0.57, P< 0.03). During the infusionstudy, u-AQP2 rate was at maximum 90 min after the infusion [baseline: 4.5ng/min (3.5-4.8); 90 min: 5 ng/min (4.5-6.0) P< 0.02]. p-AVP increased from 1.0 (0.9-1.1) to 1.5 (1.2-1.8; P< 0.002) pmol/l. There was a positive correlation between the maximum change in u-AQP2 rate and the maximum change in p-AVP (r = 0.83; P< 0.0001). It can be concluded that p-AVP and u-AQP2 are increased during thirst and hypertonic saline infusion and that u-AQP2 reflects the action of AVP on the collecting ducts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:16:17