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Titolo:
Function and spatial distribution of ion channels and transporters in cellmigration
Autore:
Schwab, A;
Indirizzi:
Inst Physiol, D-97070 Wurzburg, Germany Inst Physiol Wurzburg Germany D-97070 Physiol, D-97070 Wurzburg, Germany
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
fascicolo: 5, volume: 280, anno: 2001,
pagine: F739 - F747
SICI:
0363-6127(200105)280:5<F739:FASDOI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANINE KIDNEY-CELLS; RENAL EPITHELIAL-CELLS; PROTEIN-KINASE-C; NA+-H+ EXCHANGE; K+-CHANNEL; PLASMA-MEMBRANE; NEURONAL MIGRATION; HUMAN-NEUTROPHILS; INTRACELLULAR PH; MELANOMA-CELLS;
Keywords:
cytoskeleton; cell volume; sorting;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
110
Recensione:
Indirizzi per estratti:
Indirizzo: Schwab, A Inst Physiol, Rontgenring 9, D-97070 Wurzburg, Germany Inst Physiol Rontgenring 9 Wurzburg Germany D-97070 rg, Germany
Citazione:
A. Schwab, "Function and spatial distribution of ion channels and transporters in cellmigration", AM J P-REN, 280(5), 2001, pp. F739-F747

Abstract

Cell migration plays a central role in many physiological and pathophysiological processes, such as embryogenesis, immune defense, wound healing, or the formation of tumor metastases. Detailed models have been developed thatdescribe cytoskeletal mechanisms of cell migration. However, evidence is emerging that ion channels and transporters also play an important role in cell migration. The purpose of this review is to examine the function and subcellular distribution of ion channels and transporters in cell migration. Topics covered will be a brief overview of cytoskeletal mechanisms of migration, the role of ion channels and transporters involved in cell migration,and ways by which a polarized distribution of ion channels and transporters can be achieved in migrating cells. Moreover, a model is proposed that combines ion transport with cytoskeletal mechanisms of migration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:04:22