Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Responsiveness of canine bronchial vasculature to excitatory stimuli and to cooling
Autore:
Janssen, LJ; Hwa, LC; Netherton, S;
Indirizzi:
St Josephs Hosp, Firestone Inst Resp Hlth, Asthma Res Grp, Hamilton, ON L8N 4A6, Canada St Josephs Hosp Hamilton ON Canada L8N 4A6 , Hamilton, ON L8N 4A6, Canada McMaster Univ, Dept Med, Hamilton, ON L8N 3Z5, Canada McMaster Univ Hamilton ON Canada L8N 3Z5 ed, Hamilton, ON L8N 3Z5, Canada
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
fascicolo: 5, volume: 280, anno: 2001,
pagine: L930 - L937
SICI:
1040-0605(200105)280:5<L930:ROCBVT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRACHEAL MUCOSAL THICKNESS; BLOOD-FLOW; SMOOTH-MUSCLE; NITRIC-OXIDE; CIRCULATION; AIRWAYS; TONE; ARTERY; FLUX; RESISTANCE;
Keywords:
contraction; adrenergic response; norepinephrine; thromboxane A(2); intracellular Ca2+; protein kinase C; tyrosine kinase; mitogen-activated protein kinase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Janssen, LJ St Josephs Hosp, Firestone Inst Resp Hlth, Asthma Res Grp, L-314,50 Charlton Ave E, Hamilton, ON L8N 4A6, Canada St Josephs Hosp L-314,50Charlton Ave E Hamilton ON Canada L8N 4A6
Citazione:
L.J. Janssen et al., "Responsiveness of canine bronchial vasculature to excitatory stimuli and to cooling", AM J P-LUNG, 280(5), 2001, pp. L930-L937

Abstract

Changes in bronchial vascular tone, in part due to cooling during ventilation, may contribute to altered control of airflow during airway inflammation, asthma, and exercise-induced bronchoconstriction. We investigated the responses of canine bronchial vasculature to excitatory stimuli and cooling. Electrical stimulation evoked contractions in only some (8 of 88) tissues; these were phentolamine sensitive and augmented by N-omega-nitro-L-arginine. However, sustained contractions were evoked in all tissues by phenylephrine [concentration evoking a half-maximal response (EC50) approximate to 2 muM] or the thromboxane A(2) mimetic U-46619 (EC50 approximate to nM) and less so by beta,gamma -methylene-ATP or histamine. Cooling to room temperature markedly suppressed (approximate to 75%) adrenergic responses but had no significant effect against U-46619 responses. Adrenergic responses, but notthose to U-46619, were accompanied by an increase in intracellular Ca2+ concentration. Chelerythrine (protein kinase C antagonist) markedly antagonized adrenergic responses (mean maxima reduced 39% in artery and 86% in vein)but had no significant effect against U-46619, whereas genistein (a nonspecific tyrosine kinase inhibitor) essentially abolished responses to both agonists. We conclude that cooling of the airway wall dramatically interfereswith adrenergic control of bronchial perfusion but has little effect on thromboxane-mediated vasoconstriction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:44:50