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Titolo:
Nitric oxide decreases lung liquid production via guanosine 3 ',5 '-cyclicmonophosphate
Autore:
Cummings, JJ; Wang, HM;
Indirizzi:
E Carolina Univ, Sch Med, Dept Pediat, Greenville, NC 27858 USA E CarolinaUniv Greenville NC USA 27858 Pediat, Greenville, NC 27858 USA E Carolina Univ, Sch Med, Dept Physiol, Greenville, NC 27858 USA E Carolina Univ Greenville NC USA 27858 Physiol, Greenville, NC 27858 USA SUNY Buffalo, Dept Pediat, Buffalo, NY 14222 USA SUNY Buffalo Buffalo NY USA 14222 alo, Dept Pediat, Buffalo, NY 14222 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
fascicolo: 5, volume: 280, anno: 2001,
pagine: L923 - L929
SICI:
1040-0605(200105)280:5<L923:NODLLP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
FETAL SHEEP; PULMONARY CIRCULATION; PERINATAL-PERIOD; RELAXING FACTOR; ION-TRANSPORT; BIRTH; VASODILATION; ENDOTHELIUM; FLUID; LAMBS;
Keywords:
pulmonary circulation; guanylate cyclase; birth transition; fetus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Cummings, JJ E Carolina Univ, Sch Med, Dept Pediat, 600 Moye Blvd, Greenville, NC 27858USA E Carolina Univ 600 Moye Blvd Greenville NC USA 27858 7858USA
Citazione:
J.J. Cummings e H.M. Wang, "Nitric oxide decreases lung liquid production via guanosine 3 ',5 '-cyclicmonophosphate", AM J P-LUNG, 280(5), 2001, pp. L923-L929

Abstract

We studied the role of cGMP in nitric oxide (NO)-induced changes in lung liquid production (J(v)) in chronically instrumented fetal sheep. Forty-fivestudies were done in which J(v) was measured by a tracer dilution technique. Left pulmonary arterial flow (Q(lpa)) was measured by a Doppler flow probe. There were two series of experiments. In the first, we gave 8-bromo-cGMP, a cGMP analog, by either the pulmonary vascular or intraluminal route; in the second, we used agents to inhibit or enhance endogenous cGMP activity. When infused directly into the pulmonary circulation, 8-bromo-cGMP significantly increased Q(lpa) but had no effect on J(v). Conversely, when instilled into the lung liquid, 8-bromo-cGMP had no effect on Q(lpa) but significantly reduced J(v). Inhibition of guanylate cyclase activity with methyleneblue totally blocked, whereas phosphodiesterase inhibition with Zaprinast significantly enhanced, the effect of instilled NO on J(v). Thus the reduction in lung liquid caused by NO appears to be mediated by cGMP, perhaps through a direct effect on the pulmonary epithelium.

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Documento generato il 06/04/20 alle ore 01:50:43