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Titolo:
T cell subsets and sIL-2R/IL-2 levels in patients with glaucoma
Autore:
Yang, JJ; Patil, RV; Yu, H; Gordon, M; Wax, MB;
Indirizzi:
Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110USA Washington Univ St Louis MO USA 63110 & Visual Sci, St Louis, MO 63110USA Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 & Pharmacol, St Louis, MO 63110 USA
Titolo Testata:
AMERICAN JOURNAL OF OPHTHALMOLOGY
fascicolo: 4, volume: 131, anno: 2001,
pagine: 421 - 426
SICI:
0002-9394(200104)131:4<421:TCSASL>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NORMAL-PRESSURE GLAUCOMA; AUTOIMMUNE THYROID-DISEASES; PERIPHERAL-BLOOD; GANGLION-CELLS; IL-2 RECEPTOR; IN-VITRO; HLA-DR; LYMPHOCYTES; AUTOANTIBODIES; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Wax, MB Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, Box 8096,660 S Euclid Ave, St Louis, MO 63110 USA Washington Univ Box 8096,660 S Euclid Ave St Louis MO USA 63110 SA
Citazione:
J.J. Yang et al., "T cell subsets and sIL-2R/IL-2 levels in patients with glaucoma", AM J OPHTH, 131(4), 2001, pp. 421-426

Abstract

PURPOSE: We hypothesize that cellular immunity may have a previously unrecognized role in glaucomatous optic neuropathy, The purpose of this study isto analyze subsets of T cells and the levels of cytokine IL-2 and the soluble IL-2 receptor in peripheral blood from patients with normal pressure glaucoma (NPG) or primary open angle glaucoma (POAG) in comparison to age-matched control subjects. METHODS: In this study, 38 patients (20 NPG; 18 POAG) and 19 controls wereincluded. sIL-2R and IL-2 were assayed by ELISA. T cell subsets were analyzed by flow cytometry and lymphocyte proliferation was used to measure the reactive ability of T cells to phytohemagglutinin (PHA). RESULTS: The frequency of CD8(+)HLA-DR+ lymphocytes were increased in patients with NPG (P = 0.008), and CD3(+)CD8(+) lymphocytes increased in both NPG (P = 0.03) and POAG patients (P = 0.0004), CD5(+) lymphocytes were higher only in POAG patients (P = 0.0012). In comparison to controls, the ratio of CD4(+)/ CD8(+) lymphocytes was similar in both groups. The mean concentrations of sIL-2R in NPG (P = 0.011) and POAG (P = 0.0023) patients were higher than that found in control subjects although IL-2 concentrations were similar in these groups. In addition, the reactive ability of T lymphocytes to the non-specific reagent (PHA) was reduced significantly in NPG (P = 0.02) and POAG patients (P = 0.04). CONCLUSION: The alterations of the cellular immune system in patients withglaucoma support our hypothesis that the immune system may play an important role in the initiation and/or sustainment of glaucomatous optic neuropathy in some patients, (Am J Ophthalmol 2001; 131:421-426. (C) 2001 by Elsevier Science Inc. All rights reserved).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:36:50