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Titolo:
Targeted genome screen of panic disorder and anxiety disorder proneness using homology to murine QTL regions
Autore:
Smoller, JW; Acierno, JS; Rosenbaum, JF; Biederman, J; Pollack, MH; Meminger, S; Pava, JA; Chadwick, LH; White, C; Bulzacchelli, M; Slaugenhaupt, SA;
Indirizzi:
Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Psychiat, Boston, MA 02114 USA Harvard Univ, Sch Med, Inst Human Genet, Boston, MA USA Harvard Univ Boston MA USA iv, Sch Med, Inst Human Genet, Boston, MA USA Massachusetts Gen Hosp, Mol Neurogenet Unit, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 net Unit, Boston, MA 02114 USA
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 2, volume: 105, anno: 2001,
pagine: 195 - 206
SICI:
0148-7299(20010308)105:2<195:TGSOPD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE TRAIT LOCI; RECOMBINANT INBRED STRAINS; BEHAVIORAL-INHIBITION; PSYCHIATRIC-DISORDERS; SEGREGATION ANALYSIS; GENETIC DISSECTION; MAJOR DEPRESSION; LINKAGE ANALYSIS; COMPLEX TRAITS; MOUSE STRAINS;
Keywords:
panic disorder; linkage analysis; genome scan; mouse genetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Smoller, JW Massachusetts Gen Hosp, Dept Psychiat, 15 Parkman St,WACC-815,Boston, MA 02114 USA Massachusetts Gen Hosp 15 Parkman St,WACC-815 Boston MA USA 02114
Citazione:
J.W. Smoller et al., "Targeted genome screen of panic disorder and anxiety disorder proneness using homology to murine QTL regions", AM J MED G, 105(2), 2001, pp. 195-206

Abstract

Family and twin studies have indicated that genes influence susceptibilityto panic and phobic anxiety disorders, but the location of the genes involved remains unknown. Animal models can simplify gene-mapping efforts by overcoming problems that complicate human pedigree studies including genetic heterogeneity and high phenocopy rates. Homology between rodent and human genomes can be exploited to map human genes underlying complex traits. We used regions identified by quantitative trait locus (QTL)-mapping of anxiety phenotypes in mice to guide a linkage analysis of a large multiplex pedigree(99 members, 75 genotyped) segregating panic disorder/agoraphobia. Two phenotypes were studied: panic disorder/agoraphobia and a phenotype ("D-type")designed to capture early-onset susceptibility to anxiety disorders. A total of 99 markers across II chromosomal regions were typed, Parametric lod score analysis provided suggestive evidence of linkage (lod=2,38) to a locuson chromosome 10q under a dominant model with reduced penetrance for the anxiety-proneness D-type) phenotype, Nonparametric (NPL) analysis provided evidence of linkage for panic disorder/agoraphobia to a locus on chromosome 12q13 (NPL=4.96, P=0.006), Modest evidence of linkage by NPL analysis was also found for the D-type phenotype to a region of chromosome 1q (peak NPL =2.05, P=0.035), While these linkage results are merely suggestive, this study illustrates the potential advantages of using mouse gene-mapping results and exploring alternative phenotype definitions in linkage studies of anxiety disorder, (C) 2001 Wiley-Liss, Inc.

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Documento generato il 02/04/20 alle ore 06:11:41