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Titolo:
Dose variance associated with calibration and administration of radiopharmaceuticals
Autore:
Dansereau, RN; Methe, BM;
Indirizzi:
Albany Med Ctr Hosp, Dept Pharm, Albany, NY 12208 USA Albany Med Ctr HospAlbany NY USA 12208 Dept Pharm, Albany, NY 12208 USA St Peters Hosp, Albany, NY USA St Peters Hosp Albany NY USASt Peters Hosp, Albany, NY USA
Titolo Testata:
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
fascicolo: 7, volume: 58, anno: 2001,
pagine: 580 - 584
SICI:
1079-2082(20010401)58:7<580:DVAWCA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Keywords:
containers; dosage; dosage schedules; indium In 111; iodine I 131; needles; radiopharmaceuticals; stability; storage; syringes; technetium Tc 99m; technetium Tc 99m medronate; thallium Tl 201;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Dansereau, RN Albany Med Ctr Hosp, Dept Pharm, MC 85,43 New Scotland Ave, Albany, NY 12208 USA Albany Med Ctr Hosp MC 85,43 New Scotland Ave Albany NY USA 12208
Citazione:
R.N. Dansereau e B.M. Methe, "Dose variance associated with calibration and administration of radiopharmaceuticals", AM J HEAL S, 58(7), 2001, pp. 580-584

Abstract

Variation in the amounts of radioactivity that is associated with dose calibration and administration of gamma-emitting radioactive drugs was studied. Health systems use radionuclide dose calibrators when they need to assay drugs for radioactivity. However, the radioactive drugs commonly used for therapeutic or diagnostic purposes are compounded and assayed in or administered from containers that differ from those containing the standard reference materials (SRMs). SRMs for four radionuclides-technetium 99m, indium 111,thallium 201, and iodine 131-were drawn up into vialws and syringe-needle assemblies of volumes and sizes represented in clinical practice. In each sample, the amount of radioactivity was calculated and compared with values obtained from three dose calibrators. In addition, over a four-month period, 101 samples of technetium Tc 99m medronate injection with a desired activity of 20 mCi were prepared in syringes: the radioactive dose in each syringe was calibrated for administration to a patient at a specific time that day. The amounts of radioactivity at the time of preparation and the time ofadministration, the amount remaining in the syringe and needle after administration, and the amount reported as administered were recorded. Measurement with the dose calibrators of the SRMs in containers supplied by the National Institute of Standards and Technology showed radioactivity within 10% of the labeled amount, the percentage of variation regulations allow. Measurements of the SRMs in syringe-needle assemblies were within 10% for technetium 99m and thallium 201,9-16% foridoine 131,and 15-26% for indium 111. The individual doses of technetium 99m medronate injection were, onaverage, administered on time, but doses were administered up to 75 minutes before and 107 minutes after the calibration time. The mean +/- S.D. amount administered was 19.0 +/- 1.34 mCi. The mean +/- S.D. amount reported administered was 20 +/- 0.24 mCi. How radiopharmaceuticals were dose calibrated and administered influenced the actual dose available to patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:48:39