Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Dose-dependent decrease in glial fibrillary acidic protein-immunoreactivity in rat cerebellum after lifelong ethanol consumption
Autore:
Rintala, J; Jaatinen, P; Kiianmaa, K; Riikonen, J; Kemppainen, O; Sarviharju, M; Hervonen, A;
Indirizzi:
Tampere Univ, Sch Publ Hlth, FIN-33700 Tampere, Finland Tampere Univ Tampere Finland FIN-33700 Hlth, FIN-33700 Tampere, Finland Tampere Univ Hosp, Dept Internal Med, FIN-33700 Tampere, Finland Tampere Univ Hosp Tampere Finland FIN-33700 , FIN-33700 Tampere, Finland Natl Publ Hlth Inst, Dept Mental Hlth & Alcohol Res, FIN-00101 Helsinki, Finland Natl Publ Hlth Inst Helsinki Finland FIN-00101 N-00101 Helsinki, Finland
Titolo Testata:
ALCOHOL
fascicolo: 1, volume: 23, anno: 2001,
pagine: 1 - 8
SICI:
0741-8329(200101)23:1<1:DDIGFA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; AGE-RELATED INCREASES; ALCOHOL-CONSUMPTION; GENE-EXPRESSION; HIPPOCAMPAL-FORMATION; BRAIN-DEVELOPMENT; CEREBRAL-CORTEX; LOCUS-COERULEUS; IMAGE-ANALYSIS; MESSENGER-RNA;
Keywords:
ethanol; astrocytes; intermediate filaments; glial fibrillary acidic protein; aging; brain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Rintala, J Tampere Univ, Sch Publ Hlth, Box 607, Tampere 33101, Finland Tampere Univ Box 607 Tampere Finland 33101 pere 33101, Finland
Citazione:
J. Rintala et al., "Dose-dependent decrease in glial fibrillary acidic protein-immunoreactivity in rat cerebellum after lifelong ethanol consumption", ALCOHOL, 23(1), 2001, pp. 1-8

Abstract

The effects of aging and lifelong ethanol consumption on astrocytic morphology and glial fibrillary acidic protein-immunoreactivity (GFAP-IR) in the cerebellar vermis obtained from ethanol-preferring Alko, Alcohol (AA) rats were analyzed by using computer-assisted image analysis. The ethanol-consuming animals (both male and female) were given ethanol(10%-12%, vol./vol.) as the only available fluid for 21 months (from age 3 to 24 months), whereasthe young (3 months) and the old (24 months) controls received water. In the male rats, but not in the female rats, an age-related decrease in GFAP-IR was found in folia II, VII, and X of the molecular layer, and in turn, anage-related increase was found in folium X of the granular layer, indicating opposite changes in GFAP-IR for male rats due to aging in adjacent brainregions. In the female rats, 21 months of daily average ethanol consumption of 6.6 g/kg resulted in decreased GFAP-IR in folium VII of the molecular layer, and the decrease in cerebellar GFAP-IR correlated with the average daily ethanol intake (r = -.886, P=.019) when folia II, IV, VII, and X were analyzed together. No effect of ethanol on GFAP-IR was detected in the granular layer or in the central white matter of the female rats. There was no change in GFAP-IR in any of the three cerebellar layers of the male rats with average daily ethanol consumption of 3.2 g/kg. These results indicate that the Bergmann glial fibers are the GFAP-expressing structures of the cerebellum most sensitive to moderate-to-heavy chronic ethanol exposure and that this effect is dose dependent. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 10:33:43