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Titolo:
Ocular perfusion and age-related macular degeneration
Autore:
Ciulla, TA; Harris, A; Martin, BJ;
Indirizzi:
Indiana Univ, Sch Med, Indianapolis, IN USA Indiana Univ Indianapolis IN USA ana Univ, Sch Med, Indianapolis, IN USA
Titolo Testata:
ACTA OPHTHALMOLOGICA SCANDINAVICA
fascicolo: 2, volume: 79, anno: 2001,
pagine: 108 - 115
SICI:
1395-3907(200104)79:2<108:OPAAMD>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL SUBRETINAL NEOVASCULARIZATION; RETINAL-PIGMENT EPITHELIUM; SYSTEMIC VASCULAR-DISEASE; ENDOTHELIAL GROWTH-FACTOR; NORMAL-TENSION GLAUCOMA; BRUCH MEMBRANE CHANGE; GANGLION-CELL DEATH; BEAVER DAM EYE; CHOROIDAL NEOVASCULARIZATION; STARGARDT-DISEASE;
Keywords:
age-related macular degeneration; ocular perfusion; blood flow; choriod; choriocapillaris; retinal circulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
99
Recensione:
Indirizzi per estratti:
Indirizzo: Harris, A IUMC, 702 Rotary Circle, Indianapolis, IN 46260 USA IUMC 702 Rotary Circle Indianapolis IN USA 46260 s, IN 46260 USA
Citazione:
T.A. Ciulla et al., "Ocular perfusion and age-related macular degeneration", ACT OPHTH S, 79(2), 2001, pp. 108-115

Abstract

Purpose: To review the role of ocular perfusion in the pathophysiology of age-related macular degeneration (AMD), the leading cause of irreversible blindness in the industrialized world,Methods: Medline search of the literature published in English or with English abstracts from 1966 to 2000 was performed using various combinations of relevant key words,Results: Vascular defects have been identified in both nonexudative and exudative AMD patients using fluorescein angiographic methods, laser Doppler flowmetry, indocyanine green angiography, and color Doppler imaging. Conclusion: Although these studies lend some support to the vascular pathogenesis of AMD, it is not possible to determine if the choroidal perfusion abnormalities play a causative role in nonexudative AMD, if they are simplyan association with another primary alteration, such as a primary RPE defect or a genetic defect at the photoreceptor level, or if they are more strongly associated with one particular form of this heterogeneous disease, Further study is warranted.

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Documento generato il 21/10/20 alle ore 11:18:41