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Titolo:
Structural studies of cysteine proteases and their inhibitors
Autore:
Grzonka, Z; Jankowska, E; Kasprzykowski, F; Kasprzykowska, R; Lamkiewicz, L; Wiczk, W; Wieczerzak, E; Ciarkowski, J; Drabik, P; Janowski, R; Kozak, M; Jaskolski, M; Grubb, A;
Indirizzi:
Univ Gdansk, Fac Chem, Dept Organ Chem, PL-80952 Gdansk, Poland Univ Gdansk Gdansk Poland PL-80952 t Organ Chem, PL-80952 Gdansk, Poland Adam Mickiewicz Univ, Fac Chem, PL-60780 Poznan, Poland Adam Mickiewicz Univ Poznan Poland PL-60780 hem, PL-60780 Poznan, Poland Adam Mickiewicz Univ, Fac Phys, PL-60780 Poznan, Poland Adam Mickiewicz Univ Poznan Poland PL-60780 hys, PL-60780 Poznan, Poland Polish Acad Sci, Inst Bioorgan Chem, Ctr Biocrystallog Res, Poznan, PolandPolish Acad Sci Poznan Poland em, Ctr Biocrystallog Res, Poznan, Poland Univ Lund Hosp, Dept Clin Chem, S-22185 Lund, Sweden Univ Lund Hosp LundSweden S-22185 Dept Clin Chem, S-22185 Lund, Sweden
Titolo Testata:
ACTA BIOCHIMICA POLONICA
fascicolo: 1, volume: 48, anno: 2001,
pagine: 1 - 20
SICI:
0001-527X(2001)48:1<1:SSOCPA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CYSTATIN-C; HEREDITARY CEREBRAL-HEMORRHAGE; RAY CRYSTAL-STRUCTURE; LOW-MOLECULAR-WEIGHT; AMINO-ACID-SEQUENCE; N-TERMINAL SEGMENT; HUMAN STEFIN-A; PROTEINASE-INHIBITOR; CHICKEN CYSTATIN; GAMMA-TRACE;
Keywords:
cysteine proteases; cystatins; synthetic inhibitors; structure-activity relationship;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
110
Recensione:
Indirizzi per estratti:
Indirizzo: Grzonka, Z Univ Gdansk, Fac Chem, Dept Organ Chem, J Sobieskiego 18, PL-80952 Gdansk,Poland Univ Gdansk J Sobieskiego 18 Gdansk Poland PL-80952 nsk,Poland
Citazione:
Z. Grzonka et al., "Structural studies of cysteine proteases and their inhibitors", ACT BIOCH P, 48(1), 2001, pp. 1-20

Abstract

Cysteine proteases (CPs) are responsible for many biochemical processes occurring in living organisms and they have been implicated in the development and progression of several diseases that involve abnormal protein turnover. The activity of CPs is regulated among others by their specific inhibitors: cystatins. The main aim of this review is to discuss the structure-activity relationships of cysteine proteases and cystatins, as well as of some synthetic inhibitors of cysteine proteases structurally based on the binding fragments of cystatins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 09:53:42