Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A COMPUTER-SIMULATION OF THE HEMODYNAMIC-EFFECTS OF INTRACRANIAL ARTERIOVENOUS MALFORMATION OCCLUSION
Autore:
ORNSTEIN E; BLESSER WB; YOUNG WL; PILESPELLMAN J;
Indirizzi:
COLUMBIA UNIV,COLL PHYS & SURG,DEPT ANESTHESIOL,630 W 168 ST NEW YORKNY 10032 COLUMBIA UNIV,COLL PHYS & SURG,DEPT RADIOL NEW YORK NY 00000 COLUMBIA UNIV,COLL PHYS & SURG,DEPT NEUROL SURG NEW YORK NY 00000 POLYTECH INST NEW YORK BROOKLYN NY 00000
Titolo Testata:
Neurological research
fascicolo: 5, volume: 16, anno: 1994,
pagine: 345 - 352
SICI:
0161-6412(1994)16:5<345:ACOTHO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFUSION-PRESSURE BREAKTHROUGH; BLOOD-FLOW; TRANSCRANIAL DOPPLER; HEMODYNAMICS; MODEL; EMBOLIZATION;
Keywords:
ARTERIOVENOUS MALFORMATION; MATHEMATICAL MODEL; CEREBRAL BLOOD FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
E. Ornstein et al., "A COMPUTER-SIMULATION OF THE HEMODYNAMIC-EFFECTS OF INTRACRANIAL ARTERIOVENOUS MALFORMATION OCCLUSION", Neurological research, 16(5), 1994, pp. 345-352

Abstract

To study the effect of AVM occlusion on cerebrovascular haemodynamics, a simplified model was simulated consisting of a feeding artery supplying a capillary bed in parallel with a fistula-like malformation, both emptying into a draining vein. An electrical circuit analogue of the physiologic system was developed using lumped proximal and distal pressure dependent resistances, and capacitors representing vascular compliance. Autoregulation was introduced as a pressure varying precapillary arteriolar resistance. Equations derived from the circuit model were simulated using a graphical modeling program. The model successfully simulates phenomena angiographically observed during embolization procedures. Fistula pressure is shown to rapidly fall following proximalAVM occlusion, in contrast to a marked rise seen with distal occlusion, which is associated with biphasic flow into and out of the fistula and the arterial feeder. The model predicts an increase in capillary pressure and capillary flow which, depending on the magnitude of the flow increase and the state of autoregulation, may result either in reversal of ischaemia or hyperperfusion injury. Vascular overload is predicted in the absence of autoregulation. There is, however, little potential for vascular overload when autoregulation is intact. The model represents a first step in the mathematical characterization of the phenomenon of hyperperfusion following

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 01:21:07