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Titolo:
Virulence of mousepox virus is independent of serpin-mediated control of cellular cytotoxicity
Autore:
Wallich, R; Simon, MM; Mullbacher, A;
Indirizzi:
Australian Natl Univ, John Curtin Sch Med Res, Div Cell Biol & Immunol, Canberra, ACT 2601, Australia Australian Natl Univ Canberra ACT Australia 2601 rra, ACT 2601, Australia Univ Heidelberg, Inst Immunol, D-6900 Heidelberg, Germany Univ HeidelbergHeidelberg Germany D-6900 ol, D-6900 Heidelberg, Germany Max Planck Inst Immunbiol, D-7800 Freiburg, Germany Max Planck Inst Immunbiol Freiburg Germany D-7800 7800 Freiburg, Germany
Titolo Testata:
VIRAL IMMUNOLOGY
fascicolo: 1, volume: 14, anno: 2001,
pagine: 71 - 81
SICI:
0882-8245(2001)14:1<71:VOMVII>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERINE PROTEASE INHIBITOR; VACCINIA VIRUS; COWPOX VIRUS; CYTOKINE RECEPTORS; ECTROMELIA VIRUS; HOST-RANGE; GRANZYME-B; T-CELLS; APOPTOSIS; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Mullbacher, A Australian Natl Univ, John Curtin Sch Med Res, Div Cell Biol& Immunol, POB 334, Canberra, ACT 2601, Australia Australian Natl Univ POB334 Canberra ACT Australia 2601 lia
Citazione:
R. Wallich et al., "Virulence of mousepox virus is independent of serpin-mediated control of cellular cytotoxicity", VIRAL IMMUN, 14(1), 2001, pp. 71-81

Abstract

We have investigated whether the differential virulence seen of two Ectromelia (Ect) strains, Ect(Moscow) and Ect(Hampstead) egg, is due to mutation or differential regulation of their serpins (SPI), Poxvirus encoded serine proteinase inhibitors (serpins) have been shown to interfere with cytolyticactivity of leukocytes and can also determine virulence, We show that the deduced amino acid sequences of SPI-1, 2, and 3 are identical for the highly virulent Ect(Moscow) and the low virulent Ect(Hampstead) strains and thatthe two viruses express similar potential to inhibit T-cell cytotoxicity, in particular, Fas-mediated target cell lysis, by allorective effecters. Virus titres in wild type B6 mice were effectively controlled very early after inoculation with Ect(Hampstead) as compared with Ect(Moscow), but lack ofperforin renders B6 mice similarly susceptible to both virus strains. The data demonstrate that in Ect infection the perforin-mediated cytolytic pathway is not the primary target of serpins and suggest that the apparent attenuation of Ect(Hampstead) Seen in B6 mice is due to control elements distinct from SRI-1, 2, and 3.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 00:28:54