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Titolo:
Establishment of gene-vaccinated skin grafting against Toxoplasma gondii infection in mice
Autore:
Saito, S; Aosai, F; Rikihisa, N; Mun, HS; Norose, K; Chen, M; Kuroki, T; Asano, T; Ochiai, T; Hata, H; Ichinose, M; Yano, A;
Indirizzi:
Chiba Univ, Sch Med, Dept Parasitol, Chuo Ku, Chiba 2608670, Japan Chiba Univ Chiba Japan 2608670 Parasitol, Chuo Ku, Chiba 2608670, Japan Chiba Univ, Sch Med, Chiba Univ Hosp, Dept Plast & Reconstruct Surg, Chiba2608670, Japan Chiba Univ Chiba Japan 2608670 t & Reconstruct Surg, Chiba2608670, Japan Chiba Univ, Sch Med, Dept Surg 2, Chiba 2608670, Japan Chiba Univ Chiba Japan 2608670 ch Med, Dept Surg 2, Chiba 2608670, Japan
Titolo Testata:
VACCINE
fascicolo: 15-16, volume: 19, anno: 2001,
pagine: 2172 - 2180
SICI:
0264-410X(20010228)19:15-16<2172:EOGSGA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENDRITIC CELLS; ANTIGEN PRESENTATION; PROTECTIVE IMMUNITY; INTRACELLULAR INFECTION; VIRUS CHALLENGE; SAG1 GENE; IN-VIVO; IMMUNIZATION; SUSCEPTIBILITY; INTERLEUKIN-12;
Keywords:
gene-vaccinated skin graft; T. gondii; Langerhans cells; dendritic cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Yano, A Chiba Univ, Sch Med, Dept Parasitol, Chuo Ku, 1-8-1 Inohana, Chiba2608670, Japan Chiba Univ 1-8-1 Inohana Chiba Japan 2608670 Chiba 2608670, Japan
Citazione:
S. Saito et al., "Establishment of gene-vaccinated skin grafting against Toxoplasma gondii infection in mice", VACCINE, 19(15-16), 2001, pp. 2172-2180

Abstract

Vaccine effects of in vivo gene-vaccinated skin graft were evaluated against Toxoplasma gondii (T. gondii) infection. By using a gene gun, cDNA coding T. gondii SAG1 molecule was intracutaneously vaccinated into C57BL/6 (B6;a susceptible strain), BALB/c (a resistant strain) and (C57BL/6 x BALB/c) F1 (CBF1) mice, and the gene- vaccinated skin of these strains was transplanted to CBF1 mice. Regarding the antibody production against SAG1, CBF1-recipient mice transplanted with the SAG1 gene-vaccinated B6 skin were high responders, whereas CBF1 mice skin grafted with vaccinated skin of both BALB/c and CBF1 mice were low responders. The donor-derived LC/DC migrated to the draining lymph nodes of the recipients from the skin graft within 3 days. The vaccine effect against T. gondii challenge infection was obtained in CBF1 mice which received the skin graft of the SAG1 gene-vaccinated BALB/c mice. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 19:13:45