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Titolo:
Potency of clinical group B streptococcal conjugate vaccines
Autore:
Paoletti, LC;
Indirizzi:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Channing Lab, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Med, Channing Lab, Boston, MA 02115 USA
Titolo Testata:
VACCINE
fascicolo: 15-16, volume: 19, anno: 2001,
pagine: 2118 - 2126
SICI:
0264-410X(20010228)19:15-16<2118:POCGBS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCOCONJUGATE VACCINES; IMMUNOGENICITY; MICE; ANTIBODY; BABOONS; ANIMALS; IA; IB;
Keywords:
maternal vaccination; neonatal infections; glycoconjugates; women's health; perinatal infections; group B streptococci; potency; stability; exclusion criteria;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Paoletti, LC Harvard Univ, Brigham & Womens Hosp, Sch Med, Channing Lab, 181 Longwood Ave, Boston, MA 02115 USA Harvard Univ 181 Longwood Ave Boston MA USA 02115 A 02115 USA
Citazione:
L.C. Paoletti, "Potency of clinical group B streptococcal conjugate vaccines", VACCINE, 19(15-16), 2001, pp. 2118-2126

Abstract

The potency of clinical group B streptococcal (GBS) capsular polysaccharide-protein conjugate vaccines has been assessed with use of a mouse maternalvaccination-neonatal pup challenge model of GBS disease. Two of the three conjugated GBS vaccines bottled as liquid preparations showed a potency reduction from 100% to less than or equal to 50% in 3 years; whereas all six vaccines bottled as lyophilized preparations with sucrose excipient exhibited no loss of potency Juring the same span of time. A reconstituted GBS conjugate vaccine remained potent and antigenically intact after 31 days' storage at 2-8 degreesC. These data suggest that lyophilization in the presence of sucrose extends the potency of GBS conjugate vaccines. (C) 2001 ElsevierScience Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 13:42:54