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Titolo:
DNA vaccination in mice using HIV-1 nef, rev and tat genes in self-replicating pBN-vector
Autore:
Tahtinen, M; Strengell, M; Collings, A; Pitkanen, J; Kjerrstrom, A; Hakkarainen, K; Peterson, P; Kohleisen, B; Wahren, B; Ranki, A; Ustav, M; Krohn, K;
Indirizzi:
Tampere Univ, Inst Med Technol, Tampere 33014, Finland Tampere Univ Tampere Finland 33014 t Med Technol, Tampere 33014, Finland Karolinska Inst, Microbiol & Tumorbiol Ctr, Stockholm, Sweden Karolinska Inst Stockholm Sweden iol & Tumorbiol Ctr, Stockholm, Sweden Tampere Univ, Sch Med, Tampere 33014, Finland Tampere Univ Tampere Finland 33014 Univ, Sch Med, Tampere 33014, Finland GSF, Natl Ctr Hlth & Environm, Inst Mol Virol, Neuherberg, Germany GSF Neuherberg Germany & Environm, Inst Mol Virol, Neuherberg, Germany Univ Helsinki, Dept Dermatol, Helsinki, Finland Univ Helsinki Helsinki Finland lsinki, Dept Dermatol, Helsinki, Finland Estonian Bioctr, Dept Microbiol & Virol, Tartu, Estonia Estonian Bioctr Tartu Estonia r, Dept Microbiol & Virol, Tartu, Estonia Univ Tartu, EE-50090 Tartu, Estonia Univ Tartu Tartu Estonia EE-50090Univ Tartu, EE-50090 Tartu, Estonia
Titolo Testata:
VACCINE
fascicolo: 15-16, volume: 19, anno: 2001,
pagine: 2039 - 2047
SICI:
0264-410X(20010228)19:15-16<2039:DVIMUH>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; CELLULAR IMMUNE-RESPONSES; NONHUMAN-PRIMATES; T-CELLS; PROTEIN; EXPRESSION; IMMUNIZATION; SPECIFICITY; ACTIVATION; ANTIBODIES;
Keywords:
DNA vaccination; HIV-1; nef; rev; tat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Tahtinen, M Tampere Univ, Inst Med Technol, Tampere 33014, Finland TampereUniv Tampere Finland 33014 l, Tampere 33014, Finland
Citazione:
M. Tahtinen et al., "DNA vaccination in mice using HIV-1 nef, rev and tat genes in self-replicating pBN-vector", VACCINE, 19(15-16), 2001, pp. 2039-2047

Abstract

The immunogenicity of a self-replicating DNA-vector containing HIV-1 nef gene (pBN-Nef) was characterized using various DNA delivery methods. In addition, gene gun immunisation was used for assessing immunogenicity of two other HIV-1 genes (rev and tat) given in the same vector. The pBN-Nef was themost immunogenic raising both humoral and cell-mediated immune responses in mice; these responses lasted for up to six months. The pBN-Nef vector wasimmunogenic also when given intramuscularly or intradermally. The pBN-Rev construct did not elicit humoral responses but did elicit proliferative as well as CTL-response against the corresponding protein. The pBN-Tat was a pour immunogen in all respects. The antibodies elicited with various DNA delivery methods belonged to different antibody subclasses; however, two main epitopes in Nef were frequently recognized by all of them. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 15:29:22