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Titolo:
Clinical relevance of lower Hib response in DTPa-based combination vaccines
Autore:
Poolman, J; Kaufhold, A; De Grave, D; Goldblatt, D;
Indirizzi:
Inst Child Hlth, Immunobiol Unit, London WC1N 1EH, England Inst Child Hlth London England WC1N 1EH l Unit, London WC1N 1EH, England SmithKline Beecham Biol, Rixensart, Belgium SmithKline Beecham Biol Rixensart Belgium cham Biol, Rixensart, Belgium
Titolo Testata:
VACCINE
fascicolo: 17-19, volume: 19, anno: 2001,
pagine: 2280 - 2285
SICI:
0264-410X(20010321)19:17-19<2280:CROLHR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLUENZAE TYPE-B; CAPSULAR POLYSACCHARIDE; ACELLULAR PERTUSSIS; CONJUGATE VACCINES; PROTECTIVE LEVEL; SERUM ANTIBODIES; OPSONIC ACTIVITY; IMMUNIZATION; AVIDITY; INFANTS;
Keywords:
Hib; avidity; opsonophagocytosis; combination vaccines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Goldblatt, D Inst Child Hlth, Immunobiol Unit, 30 Guilford St, London WC1N1EH, England Inst Child Hlth 30 Guilford St London England WC1N 1EH gland
Citazione:
J. Poolman et al., "Clinical relevance of lower Hib response in DTPa-based combination vaccines", VACCINE, 19(17-19), 2001, pp. 2280-2285

Abstract

Combination vaccines are essential to enable administration of all the required antigens in routine infant immunisation schedules at any single visit. Some combinations of diphtheria-tetanus-acellular pertussis (DTPa) with Haemophilus influenzae type b (Hib) conjugate vaccines have been shown to result in lower Hib titres than when Hib is administered separately. While confirming that a primary series with a DTPa-HBV-IPV/Hib combination gives lower antibody levels than separate Hib conjugates, we show that the nature (isotype and IgG subclasses) and function (avidity and opsonic activity) of the antibodies are the same, and immunologic memory is induced. It is likely therefore that the DTPa-HBV-IPV/Hib combination will be efficacious against Hib disease. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 11:03:00